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Previous studies in\n                    <jats:italic>\n                      Nipbl\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice suggested that heart development is abnormal as soon as cardiogenic tissue is formed. To investigate this, we performed single-cell RNA sequencing on wild-type and\n                    <jats:italic>\n                      Nipbl\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mouse embryos at gastrulation and early cardiac crescent stages.\n                    <jats:italic>\n                      Nipbl\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    embryos had fewer mesoderm cells than wild-type and altered proportions of mesodermal cell subpopulations. These findings were associated with underexpression of genes implicated in driving specific mesodermal lineages. In addition,\n                    <jats:italic>Nanog<\/jats:italic>\n                    was found to be overexpressed in all germ layers, and many gene expression changes observed in\n                    <jats:italic>\n                      Nipbl\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    embryos could be attributed to\n                    <jats:italic>Nanog<\/jats:italic>\n                    overexpression. These findings establish a link between\n                    <jats:italic>Nipbl<\/jats:italic>\n                    deficiency,\n                    <jats:italic>Nanog<\/jats:italic>\n                    overexpression, and gene expression dysregulation\/lineage misallocation, which ultimately manifest as birth defects in\n                    <jats:italic>\n                      Nipbl\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    animals and Cornelia de Lange syndrome.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adl4239","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:59:03Z","timestamp":1710943143000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Gastrulation-stage gene expression in\n                    <i>Nipbl<\/i>\n                    <sup>+\/\u2212<\/sup>\n                    mouse embryos foreshadows the development of syndromic birth defects"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-9195","authenticated-orcid":true,"given":"Stephenson","family":"Chea","sequence":"first","affiliation":[{"name":"Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, CA 92697, USA."},{"name":"Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6438-171X","authenticated-orcid":true,"given":"Jesse","family":"Kreger","sequence":"additional","affiliation":[{"name":"Department of Quantitative and Computational Biology, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90089, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha E.","family":"Lopez-Burks","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, CA 92697, USA."},{"name":"Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-7907","authenticated-orcid":true,"given":"Adam L.","family":"MacLean","sequence":"additional","affiliation":[{"name":"Department of Quantitative and Computational Biology, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90089, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4380-5525","authenticated-orcid":true,"given":"Arthur D.","family":"Lander","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, CA 92697, USA."},{"name":"Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3676-2499","authenticated-orcid":true,"given":"Anne L.","family":"Calof","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, CA 92697, USA."},{"name":"Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA."},{"name":"Department of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA 92697, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"1","article-title":"Update on overall prevalence of major birth defects\u2013Atlanta, Georgia, 1978\u20132005","volume":"57","author":"Centers for Disease Control and Prevention","year":"2008","unstructured":"Centers for Disease Control and Prevention, Update on overall prevalence of major birth defects\u2013Atlanta, Georgia, 1978\u20132005. 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