{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:47:47Z","timestamp":1789609667056,"version":"build-2803163510"},"reference-count":82,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"15","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:p>Temporally coordinated neural activity is central to nervous system function and purposeful behavior. Still, there is a paucity of evidence demonstrating how this coordinated activity within cortical and subcortical regions governs behavior. We investigated this between the primary motor (M1) and contralateral cerebellar cortex as rats learned a neuroprosthetic\/brain-machine interface (BMI) task. In neuroprosthetic task, actuator movements are causally linked to M1 \u201cdirect\u201d neurons that drive the decoder for successful task execution. However, it is unknown how task-related M1 activity interacts with the cerebellum. We observed a notable 3 to 6 hertz coherence that emerged between these regions\u2019 local field potentials (LFPs) with learning that also modulated task-related spiking. We identified robust task-related indirect modulation in the cerebellum, which developed a preferential relationship with M1 task\u2013related activity. Inhibiting cerebellar cortical and deep nuclei activity through optogenetics led to performance impairments in M1-driven neuroprosthetic control. Together, these results demonstrate that cerebellar influence is necessary for M1-driven neuroprosthetic control.<\/jats:p>","DOI":"10.1126\/sciadv.adm8246","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T13:58:21Z","timestamp":1712930301000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":44,"title":["Cortico-cerebellar coordination facilitates neuroprosthetic control"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-7498","authenticated-orcid":true,"given":"Aamir","family":"Abbasi","sequence":"first","affiliation":[{"name":"Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-4253","authenticated-orcid":true,"given":"Rohit","family":"Rangwani","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA."},{"name":"Bioengineering Graduate Program, Department of Biomedical Engineering, Henry Samueli School of Engineering, University of California-Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Bowen","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Fealy","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4764-4773","authenticated-orcid":true,"given":"Nathan P.","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-7883","authenticated-orcid":true,"given":"Tanuj","family":"Gulati","sequence":"additional","affiliation":[{"name":"Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA."},{"name":"Bioengineering Graduate Program, Department of Biomedical Engineering, Henry Samueli School of Engineering, University of California-Los Angeles, CA, USA."},{"name":"Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA."},{"name":"Department of Medicine, David Geffen School of Medicine, and Department of Bioengineering, Henry Samueli School of Engineering, University of California-Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-23-08432.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.019"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63382-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb07563.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002263"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0407-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0011-23.2023"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(02)00929-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902960405"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"O. 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