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MLL\/WDR5 localize to the pericentriolar material and interact with centriolar satellite protein Cep72 and \u03b3-tubulin ring complex proteins (\u03b3-TuRCs). MLL\/WDR5 promote the localization of \u03b3-TuRCs and structural proteins like AKAP9 to the centrosome during interphase and mitosis, a phenotype also observed in cells derived from patients with WSS. During mitosis, loss of MLL, WDR5, and Cep72 affects spindle formation and leads to misaligned chromosomes. Last, we show that MLL and WDR5 recruit Cep72 to the centrosome. Our studies provide insight into an undiscovered role of MLL at the centrosome and elucidate how centriolar satellite proteins like Cep72 can be recruited to the centrosome.<\/jats:p>","DOI":"10.1126\/sciadv.adn0086","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:59:34Z","timestamp":1733943574000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["MLL\/WDR5 complex recruits centriolar satellite protein Cep72 to regulate microtubule nucleation and spindle formation"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5405-689X","authenticated-orcid":true,"given":"Swathi","family":"Chodisetty","sequence":"first","affiliation":[{"name":"Laboratory of Cell Cycle Regulation, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad 500039, India."},{"name":"Graduate Studies, Manipal Academy of Higher Education, Manipal 567104, 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