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CIML NK cells transduced with a chimeric antigen receptor (CAR) targeting the membrane-proximal domain of mesothelin (MSLN) further improved the antitumor responses against MSLN-expressing EOC cells and patient-derived xenograft tumor cells. CAR arming of the CIML NK cells subtanstially reduced their dysfunction in patient-derived ascites fluid with transcriptomic changes related to altered metabolism and tonic signaling as potential mechanisms. Lastly, the adoptive transfer of MSLN-CAR CIML NK cells demonstrated remarkable inhibition of tumor growth and prevented metastatic spread in xenograft mice, supporting their potential as an effective therapeutic strategy in EOC.<\/jats:p>","DOI":"10.1126\/sciadv.adn0881","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T17:59:05Z","timestamp":1720807145000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":49,"title":["CAR memory\u2013like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-1565","authenticated-orcid":true,"given":"Mubin","family":"Tarannum","sequence":"first","affiliation":[{"name":"Division of Transplantation and Cellular Therapies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 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