{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:30:23Z","timestamp":1789219823781,"version":"build-2803163510"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"32","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,8,9]]},"abstract":"<jats:p>Episodic memory in older adults is varied and perceived to rely on numbers of synapses or dendritic spines. We analyzed 2157 neurons among 128 older individuals from the Religious Orders Study and Rush Memory and Aging Project. Analysis of 55,521 individual dendritic spines by least absolute shrinkage and selection operator regression and nested model cross-validation revealed that the dendritic spine head diameter in the temporal cortex, but not the premotor cortex, improved the prediction of episodic memory performance in models containing \u03b2 amyloid plaque scores, neurofibrillary tangle pathology, and sex. These findings support the emerging hypothesis that, in the temporal cortex, synapse strength is more critical than quantity for memory in old age.<\/jats:p>","DOI":"10.1126\/sciadv.adn5181","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:02:20Z","timestamp":1723053740000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Dendritic spine head diameter predicts episodic memory performance in older adults"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-4044","authenticated-orcid":true,"given":"Courtney K.","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2513-2774","authenticated-orcid":true,"given":"Evan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-8708","authenticated-orcid":true,"given":"Kelsey M.","family":"Greathouse","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6231-6279","authenticated-orcid":true,"given":"Ashley B.","family":"Adamson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia P.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily H.","family":"Poovey","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall A.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-117X","authenticated-orcid":true,"given":"Hamad M.","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-941X","authenticated-orcid":true,"given":"Audrey J.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-554X","authenticated-orcid":true,"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-9211","authenticated-orcid":true,"given":"Nicholas T.","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gaiteri","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-1470","authenticated-orcid":true,"given":"Jeremy H.","family":"Herskowitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/380715a0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12533"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.09.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.09.077"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25049"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1836"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270502"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300410"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs154"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25162-w"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2013.07.002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12626"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2008.11.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.7.1367"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00260"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-11-04302.1997"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2003.09.008"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193594"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000148190"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12266"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6410-09.2010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858420945964"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02617"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.07.003"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00467-3"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.024"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.025"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5215-08.2009"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.136"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121081109"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162844"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206171109"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaw9318"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-41"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2023.100542"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07761"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.37"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13688"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5567-05.2006"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm260"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.10.5313"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.49.29051"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00574.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00539.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00811-3"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2508-13.2013"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.12.006"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3642"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1229"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.029"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5245-10.2011"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr576"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.030"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12507"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4245-05.2006"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.06.029"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.389"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt895"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101782"},{"key":"e_1_3_2_62_2","first-page":"3764","article-title":"Cross-platform synaptic network analysis of human entorhinal cortex identifies TWF2 as a modulator of dendritic spine length","volume":"43","author":"Walker C. K.","year":"2023","unstructured":"C. K. Walker, K. M. Greathouse, J. J. Tuscher, E. B. Dammer, A. J. Weber, E. Liu, K. A. Curtis, B. D. Boros, C. D. Freeman, J. V. Seo, R. Ramdas, C. Hurst, D. M. Duong, M. Gearing, C. F. Murchison, J. J. Day, N. T. Seyfried, J. H. Herskowitz, Cross-platform synaptic network analysis of human entorhinal cortex identifies TWF2 as a modulator of dendritic spine length. J. Neurosci. 43, 3764\u20133785 (2023).","journal-title":"J. Neurosci."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0379-23.2023"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330209"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00666-6"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-0582-0"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.008"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001935"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200403000-00012"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179939"},{"key":"e_1_3_2_72_2","unstructured":"B. Ghojogh M. Crowley The theory behind overfitting cross validation regularization bagging and boosting: Tutorial. arXiv:1905.12787 [stat.ML] (2019)."},{"key":"e_1_3_2_73_2","doi-asserted-by":"crossref","unstructured":"T. Hastie R. Tibshirani J. H. Friedman The Elements of Statistical Learning: Data Mining Inference and Prediction (Springer 2009).","DOI":"10.1007\/978-0-387-84858-7"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeconom.2015.02.006"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adn5181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:04:27Z","timestamp":1723053867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adn5181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":73,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2024,8,9]]}},"alternative-id":["10.1126\/sciadv.adn5181"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adn5181","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadn5181"}}