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Using the patient-derived appendix organoid (PDAO) model, we found that circulating MAIT cells treated with inflammatory cytokines elevated in APA up-regulated chemokine receptors, including CCR1, CCR3, and CCR4. They exhibited enhanced infiltration of\n            <jats:italic>Escherichia coli<\/jats:italic>\n            \u2013pulsed PDAO in a CCR1-, CCR2-, and CCR4-dependent manner. Close interactions of MAIT cells with infected organoids led to the PDAO structural destruction and death. These findings reveal a previously unidentified mechanism of MAIT cell tissue homing, their participation in tissue damage in APA, and their intricate relationship with mucosal tissues during acute intestinal inflammation in humans.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adn6331","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T17:58:25Z","timestamp":1718215105000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":32,"title":["MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-876X","authenticated-orcid":true,"given":"Yichao","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China."},{"name":"Precision Medicine and Healthcare Research Centre, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1478-9559","authenticated-orcid":true,"given":"Fei","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3926-372X","authenticated-orcid":true,"given":"Zhengyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7916-4510","authenticated-orcid":true,"given":"Bingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-2750","authenticated-orcid":true,"given":"Xingchi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 14152 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuebin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou 363000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China."},{"name":"Precision Medicine and Healthcare Research Centre, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5985-2493","authenticated-orcid":true,"given":"Dan","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China."},{"name":"Precision Medicine and Healthcare Research Centre, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-4192","authenticated-orcid":true,"given":"Wan Rong","family":"Sia","sequence":"additional","affiliation":[{"name":"Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-4539","authenticated-orcid":true,"given":"Jeffrey Y. 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