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Anatomical evidence reveals a portal system linking the SCN and the organum vasculosum of the lamina terminalis (OVLT), begging the question of the direction of blood flow and the nature of diffusible signals that flow in this specialized vasculature. Using a combination of anatomical and in vivo two-photon imaging approaches, we unequivocally show that blood flows unidirectionally from the SCN to the OVLT, that blood flow rate displays daily oscillations with a higher rate at night than in the day, and that circulating vasopressin can access portal vessels. These findings highlight a previously unknown central nervous system communication pathway, which, like that of the pituitary portal system, could allow neurosecretions to reach nearby target sites in OVLT, avoiding dilution in the systemic blood. In both of these brain portal pathways, the target sites relay signals broadly to both the brain and the rest of the body.<\/jats:p>","DOI":"10.1126\/sciadv.adn8350","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T14:04:36Z","timestamp":1718978676000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["Blood flows from the SCN toward the OVLT within a new brain vascular portal pathway"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-8043","authenticated-orcid":true,"given":"Ranjan K.","family":"Roy","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Georgia State University, Atlanta, GA, USA."},{"name":"Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-8802","authenticated-orcid":true,"given":"Yifan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Psychology, Columbia University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella K.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Psychology, Columbia University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-9369","authenticated-orcid":true,"given":"Andrew V.","family":"Aitken","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicia C.","family":"Biancardi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-739X","authenticated-orcid":true,"given":"Rae","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Psychology, Columbia University, New York, NY, USA."},{"name":"Department of Neuroscience and Behavior, Barnard College, New York, NY, USA."},{"name":"Department of Pathology and Cell Biology Graduate Program, Columbia University, New York, NY, USA."},{"name":"Zukerman Institute Affiliate, Columbia University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-0486","authenticated-orcid":true,"given":"Javier E.","family":"Stern","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, Georgia State University, Atlanta, GA, USA."},{"name":"Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"227","article-title":"Hypophysio-portal vessels and their colloid accompaniment","volume":"67","author":"Popa G. 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