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The design of a redox-active boronic ester substrate, serving as an excellent \u03b2-boron radical precursor, is the linchpin to the success of this chemistry. With the established protocol, a wide spectrum of \u03b2-boryl ketones has been rapidly synthesized, which could further undergo various C\u2500B bond transformations to give multifunctionalized products. The robustness of this catalytic strategy is underscored by its successful application in late-stage modification of drug-derived molecules and natural products. Preliminary mechanistic investigations, including several control experiments, photochemistry measurements, and computational studies, shed light on the catalytic radical reaction mechanism.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adn8401","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T17:59:07Z","timestamp":1721843947000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":38,"title":["<i>N<\/i>\n            -Heterocyclic carbene catalytic 1,2-boron migrative acylation accelerated by photocatalysis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7637-8333","authenticated-orcid":true,"given":"Hua","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."},{"name":"Anti-infective Agent 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