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To support rapid clinical translation, a continuous microfluidic preparation for HormFoam was proposed, including the power unit of perfluorocarbon nanodroplets and the pharmaceutical components Pluronic F127\u2013functionalized liposomal insulin and pramlintide. We found that HormFoam could consistently generate foams to drive drugs forward after rectal administration, which enhanced intestinal distribution and mucosa absorption, leading to systemic codelivery of insulin-pramlintide. HormFoam reproduced the physiology of endocrine pancreas for glycemic control and induced body weight loss while reversing metabolic disorders in diabetic mice with good biosafety. Therefore, HormFoam represents a state-of-the-art dual-hormone regimen with the potential to address unmet needs in diabetes management.<\/jats:p>","DOI":"10.1126\/sciadv.adn8695","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T14:01:55Z","timestamp":1724853715000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["A temperature-responsive dual-hormone foam nanoengine improves rectal absorptivity of insulin-pramlintide for diabetes treatment"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4166-6947","authenticated-orcid":true,"given":"Shujun","family":"Feng","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China."},{"name":"College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, 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