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This reaction begins by generating a pre-aromatic intermediate (PAI) through the condensation of the ketone and\n                    <jats:italic>N<\/jats:italic>\n                    \u2032-methylpicolino-hydrazonamide (MPHA), followed by the oxidative cleavage of the PAI \u03b1-C\u2500C bond to form an alkyl radical, which is subsequently intercepted by a Ni complex, facilitating the formation of diverse C(\n                    <jats:italic>\n                      sp\n                      <jats:sup>3<\/jats:sup>\n                    <\/jats:italic>\n                    )\u2013C(\n                    <jats:italic>\n                      sp\n                      <jats:sup>2<\/jats:sup>\n                    <\/jats:italic>\n                    )\/C(\n                    <jats:italic>sp<\/jats:italic>\n                    ) bonds with remarkable generality. This protocol features a one-pot reaction capability, high regioselectivity and ring-opening efficiency, mild reaction conditions, and a broad substrate scope with excellent functional group compatibility.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ado0225","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T13:58:41Z","timestamp":1714139921000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":50,"title":["Deacylative arylation and alkynylation of unstrained ketones"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3115-9861","authenticated-orcid":true,"given":"Boyi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-902X","authenticated-orcid":true,"given":"Beibei","family":"Zhan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihang","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7396-8114","authenticated-orcid":true,"given":"Shenyou","family":"Nie","sequence":"additional","affiliation":[{"name":"Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Institute of Life Sciences and Department of Urology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-1347","authenticated-orcid":true,"given":"Xiaheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Y. 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