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Our analysis revealed the CD43+CD71+IgG+ activated B cell subset, highly enriched for SARS-CoV-2 specificities, as a juncture for ASC and MBC differentiation, with CD86+ phenotypically similar to ASCs and CD86\u2212 to IgG+ MBCs. Moreover, subpopulations within IgG+ MBCs were further identified based on CD73 and CD24 expression. Activated MBCs (CD73\u2212\/CD24lo) were predominantly SARS-CoV-2-specific, while resting MBCs (CD73+\/CD24hi) recognized prepandemic antigens. A CD95\u2212 subcluster within resting MBCs accounted for over 40% of prepandemic-specific cells, indicating long-lasting memory. These findings advance our understanding of IgG+ MBC and ASC development stages, shedding light on the decision-making process guiding their differentiation.<\/jats:p>","DOI":"10.1126\/sciadv.ado1331","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:59:36Z","timestamp":1739973576000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["Deep profiling of B cells responding to various pathogens uncovers compartments in IgG memory B cell and antibody-secreting lineages"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-9493","authenticated-orcid":true,"given":"Mathieu","family":"Claireaux","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands."},{"name":"Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-7351","authenticated-orcid":true,"given":"Gius","family":"Kerster","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands."},{"name":"Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisan H.","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands."},{"name":"Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00ebl C.","family":"Duurland","sequence":"additional","affiliation":[{"name":"Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands."},{"name":"Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-3760","authenticated-orcid":true,"given":"Alberta G. 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