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Very-early-differentiated stem cell memory T cells (T\n            <jats:sub>SCMs<\/jats:sub>\n            ) have superior self-renewal, engraftment, persistence, and anticancer efficacy, but their potential for antiviral ACT remains unknown. Here, we developed a clinically scalable protocol for expanding Epstein-Barr virus (EBV)\u2013specific T\n            <jats:sub>SCM<\/jats:sub>\n            -enriched T cells with high proportions of CD4\n            <jats:sup>+<\/jats:sup>\n            T cells and broad EBV antigen coverage. These cells showed tumor control in a xenograft model of EBV-induced lymphoma and were superior to previous ACT protocols in terms of tumor infiltration, in vivo proliferation, persistence, proportion of functional CD4\n            <jats:sup>+<\/jats:sup>\n            T cells, and diversity of EBV antigen specificity. Thus, our protocol may pave the way for the next generation of potent unmodified antigen-specific cell therapies for EBV-associated diseases, including tumors, and other indications.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ado2048","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:58:55Z","timestamp":1724435935000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Stem cell memory EBV-specific T cells control EBV tumor growth and persist in vivo"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-7548","authenticated-orcid":true,"given":"Darya","family":"Palianina","sequence":"first","affiliation":[{"name":"Department of Biomedicine, University of Basel and University Hospital Basel, Basel, 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