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The reorganization of activity is so profound that decoding of sound representation under anesthesia is not possible based on awake activity. However, population-level parameters, such as average tuning strength and population decoding accuracy, are weakly affected by anesthesia, explaining why its effect has previously gone unnoticed when comparing independently sampled neurons. Together, our results indicate that the functional organization of the auditory brainstem largely depends on the network state and is ill-defined under anesthesia. This demonstrates a remarkable sensitivity of an early sensory stage to anesthesia, which is bound to disrupt downstream processing.<\/jats:p>","DOI":"10.1126\/sciadv.ado2291","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T14:00:56Z","timestamp":1729260056000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Massive perturbation of sound representations by anesthesia in the auditory brainstem"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8300-8156","authenticated-orcid":true,"given":"Etienne","family":"Gosselin","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institut Pasteur, AP-HP, Inserm, Fondation Pour l\u2019Audition, Institut de l\u2019Audition, IHU reConnect, F-75012 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-1838","authenticated-orcid":true,"given":"Sophie","family":"Bagur","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institut Pasteur, AP-HP, Inserm, Fondation Pour l\u2019Audition, Institut de l\u2019Audition, IHU reConnect, F-75012 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9211-1960","authenticated-orcid":true,"given":"Brice","family":"Bathellier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institut Pasteur, AP-HP, Inserm, Fondation Pour l\u2019Audition, Institut de l\u2019Audition, IHU reConnect, F-75012 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"3","article-title":"Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing","volume":"4","author":"Andermann M. 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