{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:56:20Z","timestamp":1790978180131,"version":"4.1.0"},"reference-count":83,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,8,23]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>Drosophila<\/jats:italic>\n                    corneal lens is entirely composed of chitin and other apical extracellular matrix components, and it is not known how it acquires the biconvex shape that enables it to focus light onto the retina. We show here that the zona pellucida domain\u2013containing protein Dusky-like is essential for normal corneal lens morphogenesis. Dusky-like transiently localizes to the expanded apical surfaces of the corneal lens-secreting cells and prevents them from undergoing apical constriction and apicobasal contraction. Dusky-like also controls the arrangement of two other zona pellucida domain proteins, Dumpy and Piopio, external to the developing corneal lens. Loss of either\n                    <jats:italic>dusky-like<\/jats:italic>\n                    or\n                    <jats:italic>dumpy<\/jats:italic>\n                    delays chitin accumulation and disrupts the outer surface of the corneal lens. We find that artificially inducing apical constriction by activating myosin contraction is sufficient to similarly alter chitin deposition and corneal lens morphology. These results demonstrate the importance of cell shape in controlling the morphogenesis of overlying apical extracellular matrix structures such as the corneal lens.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ado4167","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T18:27:22Z","timestamp":1724264842000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":23,"title":["Apical cell expansion maintained by Dusky-like establishes a scaffold for corneal lens morphogenesis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-4720","authenticated-orcid":true,"given":"Neha","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Cell Biology, NYU Grossman School of Medicine, 540 First Avenue, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7453-107X","authenticated-orcid":true,"given":"Jessica E.","family":"Treisman","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, NYU Grossman School of Medicine, 540 First Avenue, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010238"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051407"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.12.009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005082"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.175596"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.12703\/r\/9-27"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jdb8040023"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.897087"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2018.02.006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-023-10124-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.05.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09373"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010348"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-017-0582-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385044-7.00005-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(89)90261-3"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006782"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200217"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.06.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081266"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10931-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.007"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"e_1_3_2_25_2","first-page":"e4720","article-title":"Diagnosis and long-term management of uromodulin kidney disease","volume":"11","author":"Wheeler E.","year":"2019","unstructured":"E. 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