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Huntingtin RNA-immunoprecipitation sequencing from patient-derived fibroblasts and neuronal progenitor cells expressing wild-type and mutant huntingtin revealed long noncoding RNA\n                    <jats:italic>NEAT1<\/jats:italic>\n                    as a significantly enriched transcript. Altered\n                    <jats:italic>NEAT1<\/jats:italic>\n                    levels were evident in Huntington\u2019s disease cells and postmortem brain tissues, and huntingtin knockdown decreased\n                    <jats:italic>NEAT1<\/jats:italic>\n                    levels. Huntingtin colocalized with\n                    <jats:italic>NEAT1<\/jats:italic>\n                    in paraspeckles, and we identified a high-affinity RNA motif preferred by huntingtin. This study highlights\n                    <jats:italic>NEAT1<\/jats:italic>\n                    as a huntingtin interactor, demonstrating huntingtin\u2019s involvement in RNA-mediated functions and paraspeckle regulation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ado5264","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T13:59:03Z","timestamp":1721397543000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Huntingtin is an RNA binding protein and participates in\n                    <i>NEAT1<\/i>\n                    -mediated paraspeckles"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-7774","authenticated-orcid":true,"given":"Manisha","family":"Yadav","sequence":"first","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada."},{"name":"Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada."},{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-391X","authenticated-orcid":true,"given":"Rachel J.","family":"Harding","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada."},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-9330","authenticated-orcid":true,"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-1243","authenticated-orcid":true,"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Gall-Duncan","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9900-978X","authenticated-orcid":true,"given":"Mahreen","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-2259","authenticated-orcid":true,"given":"Costanza Ferrari","family":"Bardile","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, Edwin S. 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