{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:31:23Z","timestamp":1790083883889,"version":"4.0.1"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"33","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:p>Ferroptosis, caused by disorders of iron metabolism, plays a critical role in various diseases, making the regulation of iron metabolism essential for tissue repair. In our analysis of degenerated intervertebral disc tissue, we observe a positive correlation between the concentration of extracellular iron ions (ex-iron) and the severity of ferroptosis in intervertebral disc degeneration (IVDD). Hence, inspired by magnets attracting metals, we combine polyether F127 diacrylate (FDA) with tannin (TA) to construct a magnetically attracting hydrogel (FDA-TA). This hydrogel demonstrates the capability to adsorb ex-iron and remodel the iron metabolism of cells. Furthermore, it exhibits good toughness and self-healing properties. Notably, it can activate the PI3K-AKT pathway to inhibit nuclear receptor coactivator 4\u2013mediated ferritinophagy under ex-iron enrichment conditions. The curative effect and related mechanism are further confirmed in vivo. Consequently, on the basis of the pathological mechanism, a targeted hydrogel is designed to reshape iron metabolism, offering insights for tissue repair.<\/jats:p>","DOI":"10.1126\/sciadv.ado7249","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T18:00:58Z","timestamp":1723831258000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":38,"title":["Magnetically attracting hydrogel reshapes iron metabolism for tissue repair"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1671-0085","authenticated-orcid":true,"given":"Yichang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-6477","authenticated-orcid":true,"given":"Feng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-3482","authenticated-orcid":true,"given":"Jincheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-7046","authenticated-orcid":true,"given":"Ziang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2823-2116","authenticated-orcid":true,"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0458-9866","authenticated-orcid":true,"given":"Kun","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-1610","authenticated-orcid":true,"given":"Yong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-7596","authenticated-orcid":true,"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi Road, Suzhou, Jiangsu 215006, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2023.2180019"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0305-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102825"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35294-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102707"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1042060"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30039"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207216"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.586530"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05037-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102413"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202006333"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01146H"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2022.03.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902099"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900848"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201907748"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0458-4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300303"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209685"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.371377"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2022.2162537"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.03.019"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2023.04.004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.026"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129043"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2933199"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115252"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00751-2"},{"key":"e_1_3_2_31_2","first-page":"346","article-title":"Oxygen metabolism-balanced engineered hydrogel microspheres promote the regeneration of the nucleus pulposus by inhibiting acid-sensitive complexes","volume":"24","author":"Li Z.","year":"2023","unstructured":"Z. Li, F. Cai, J. Tang, Y. Xu, K. Guo, Z. Xu, Y. Feng, K. Xi, Y. Gu, L. Chen, Oxygen metabolism-balanced engineered hydrogel microspheres promote the regeneration of the nucleus pulposus by inhibiting acid-sensitive complexes. Bioact. Mater. 24, 346\u2013360 (2023).","journal-title":"Bioact. Mater."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05447-8"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.07.154"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB01155B"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/mz500221j"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.12.004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c05454"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09854-9"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010130"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1497105"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09733-6"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6670497"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1160176"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134319"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131755"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216307"},{"key":"e_1_3_2_47_2","article-title":"Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy","volume":"29","author":"Belaidi A. A.","year":"2023","unstructured":"A. A. Belaidi, S. Masaldan, A. Southon, P. Kalinowski, K. Acevedo, A. T. Appukuttan, S. Portbury, P. Lei, P. Agarwal, S. E. Leurgans, J. Schneider, M. Conrad, A. I. Bush, S. Ayton, Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Mol. Psychiatry 29, (2023).","journal-title":"Mol. Psychiatry"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31087"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.06.019"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000238681.71537.41"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S430423"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-023-10112-1"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01210-4"},{"key":"e_1_3_2_54_2","first-page":"153","article-title":"Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration","volume":"12","author":"Shen J.","year":"2022","unstructured":"J. Shen, A. Chen, Z. Cai, Z. Chen, R. Cao, Z. Liu, Y. Li, J. Hao, Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration. Bioact. Mater. 12, 153\u2013168 (2022).","journal-title":"Bioact. Mater."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.ado7249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T18:01:53Z","timestamp":1723831313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ado7249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":53,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2024,8,16]]}},"alternative-id":["10.1126\/sciadv.ado7249"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.ado7249","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"assertion":[{"value":"2024-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eado7249"}}