{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:28:39Z","timestamp":1787016519606,"version":"build-2736575974"},"reference-count":116,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"27","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,7,4]]},"abstract":"<jats:p>\n                    The effectiveness of exosomes engineered to carry a dominantly active variant of inhibitor \u03b1 of nuclear factor \u03baB (NF-\u03baB) (I\u03baB\u03b1), super-repressor I\u03baB (srI\u03baB), that inhibits the expression of NF-\u03baB in various animal models of inflammatory diseases has been demonstrated. In this study, we used a lipopolysaccharide (LPS)\u2013induced chorioamnionitis model in pregnant nonhuman primates to explore the therapeutic potential and mode of action of srI\u03baB-loaded exosomes (Exo-srI\u03baBs). Intraamniotic injection of LPS induced infiltration of BCL2A1-positive neutrophils and CD68-positive macrophages in the extraplacental membranes, causing fetal lung injury. Conversely, administration of Exo-srI\u03baB via intraamniotic and intravenous routes (6.9\u00a0\u00d7\u00a010\n                    <jats:sup>10<\/jats:sup>\n                    and 4\u00a0\u00d7\u00a010\n                    <jats:sup>11<\/jats:sup>\n                    particle numbers, respectively) ameliorated these effects. Single-cell RNA sequencing of the decidua and bulk RNA sequencing of the choriodecidua highlighted that Exo-srI\u03baB treatment mitigated LPS-induced inflammatory pathways, particularly in macrophages, leading to a cascade effect on neutrophils through NF-\u03baB signaling inhibition. These findings underscore the potential of Exo-srI\u03baB as a therapeutic strategy for chorioamnionitis.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp0467","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T13:59:13Z","timestamp":1751464753000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Single-cell analysis of the decidua unveils the mechanism of anti-inflammatory exosomes for chorioamnionitis in nonhuman primates"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1147-1476","authenticated-orcid":true,"given":"Seung Hyun","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-9548","authenticated-orcid":true,"given":"Hojun","family":"Choi","sequence":"additional","affiliation":[{"name":"ILIAS Biologics Inc., Daejeon, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7928-1524","authenticated-orcid":true,"given":"Eun Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea."},{"name":"Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, 03087, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0056-4995","authenticated-orcid":true,"given":"Seung-Bin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Primate Resources Center (PRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1529-8930","authenticated-orcid":true,"given":"Hye-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"ILIAS Biologics Inc., Daejeon, Korea."},{"name":"Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-0271","authenticated-orcid":true,"given":"Cheolhyoung","family":"Park","sequence":"additional","affiliation":[{"name":"ILIAS Biologics Inc., Daejeon, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1459-8093","authenticated-orcid":true,"given":"Jae Kyung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-4073","authenticated-orcid":true,"given":"Seung Han","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6885-0947","authenticated-orcid":true,"given":"Ji-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Primate Resources Center (PRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-6438","authenticated-orcid":true,"given":"Chan-Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea."},{"name":"Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, 03087, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-6177","authenticated-orcid":true,"given":"Heon Yung","family":"Gee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-9136","authenticated-orcid":true,"given":"Chulhee","family":"Choi","sequence":"additional","affiliation":[{"name":"ILIAS Biologics Inc., Daejeon, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"J. 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