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These \u201cextragenital\u201d cells, marked by a lineage marker\n            <jats:italic>Nr5a1<\/jats:italic>\n            , migrate from the inguinal region into the embryonic penis and facilitate urethra closure by interacting with adjacent periurethral cells via the epidermal growth factor pathway. Ablation of\n            <jats:italic>Nr5a1<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            cells leads to severe hypospadias and alters cell differentiation in the penis. This discovery highlights the indispensable role of\n            <jats:italic>Nr5a1<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            extragenital cells in urethra closure, shedding light on the biology of penis formation and potential implications for human hypospadias.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adp0673","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T18:58:44Z","timestamp":1733511524000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["An extragenital cell population contributes to urethra closure during mouse penis development"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-2027","authenticated-orcid":true,"given":"Ciro Maurizio","family":"Amato","sequence":"first","affiliation":[{"name":"Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle 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