{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:04:51Z","timestamp":1788285891321,"version":"build-2803163510"},"reference-count":89,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,8,23]]},"abstract":"<jats:p>\n                    SARS-CoV-2 infection induces the generation of virus-specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector and memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during infection is not well understood. Following infection of C57BL\/6 mice, SARS-CoV-2\u2013specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are recruited to the respiratory tract, and a vast proportion secrete the cytotoxic molecule granzyme B. Using depleting antibodies, we found that T cells within the lungs play a minimal role in viral control, and viral clearance occurs in the absence of both CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells through 28 days postinfection. In the nasal compartment, depletion of both CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, but not individually, results in persistent, culturable virus replicating in the nasal epithelial layer through 28 days postinfection. Viral sequencing analysis revealed adapted mutations across the SARS-CoV-2 genome, including a large deletion in ORF6. Overall, our findings highlight the importance of T cells in controlling virus replication within the respiratory tract during SARS-CoV-2 infection.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp2636","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T13:58:55Z","timestamp":1724421535000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["CD4\n                    <sup>+<\/sup>\n                    and CD8\n                    <sup>+<\/sup>\n                    T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-811X","authenticated-orcid":true,"given":"Meenakshi","family":"Kar","sequence":"first","affiliation":[{"name":"Center for Childhood Infections and Vaccines of Children\u2019s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA."},{"name":"Emory Vaccine Center, Emory University, Atlanta, GA, USA."},{"name":"Emory National Primate Research Center, Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-0672","authenticated-orcid":true,"given":"Katherine E. 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