{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:20:23Z","timestamp":1791523223972,"version":"4.3.4"},"reference-count":99,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"51","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:p>\n                    The covalently attached cofactor biotin plays pivotal roles in central metabolism. The top-priority ESKAPE-type pathogens,\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    and\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    , constitute a public health challenge of global concern. Despite the fact that the late step of biotin synthesis is a validated anti-ESKAPE drug target, the primary stage remains fragmentarily understood. We report the functional definition of two BioC isoenzymes (AbBioC for\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    and KpBioC for\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    ) that act as malonyl-ACP methyltransferase and initiate biotin synthesis. The physiological requirement of biotin is diverse within ESKAPE pathogens. CRISPR-Cas9\u2013based inactivation of\n                    <jats:italic>bioC<\/jats:italic>\n                    rendered\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    and\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    biotin auxotrophic. The availability of soluble AbBioC enabled the in vitro reconstitution of DTB\/biotin synthesis. We solved two crystal structures of AbBioC bound to SAM cofactor (2.54 angstroms) and sinefungin (SIN) inhibitor (1.72 angstroms). Structural and functional study provided molecular basis for SIN inhibition of BioC. We demonstrated that BioC methyltransferase plays dual roles in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    infection and\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    colistin resistance.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp3954","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T14:01:18Z","timestamp":1734703278000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3767-4138","authenticated-orcid":true,"given":"Zhi","family":"Su","sequence":"first","affiliation":[{"name":"Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."},{"name":"College of Life Science and Technology, Guangxi University, Nanning, Guangxi 530004, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-2772","authenticated-orcid":true,"given":"Weizhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Sci-Tech Inno Center for Infection &amp; Immunity, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, School of Life Science, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-2473","authenticated-orcid":true,"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University, Xi\u2019an, Shaanxi 710072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9554-7102","authenticated-orcid":true,"given":"Yongchang","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-6139","authenticated-orcid":true,"given":"Runshi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-2254","authenticated-orcid":true,"given":"Man","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-468X","authenticated-orcid":true,"given":"Chun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-8434","authenticated-orcid":true,"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-3253","authenticated-orcid":true,"given":"Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-2353","authenticated-orcid":true,"given":"Jiuxin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shenzhen Third People\u2019s Hospital, National Clinical Research Center for Infectious Diseases, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518112, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0945-4095","authenticated-orcid":true,"given":"Zheng-Guo","family":"He","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Guangxi University, Nanning, Guangxi 530004, China."},{"name":"Taikang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, Hubei 430071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-8852","authenticated-orcid":true,"given":"Jianhua","family":"Gan","sequence":"additional","affiliation":[{"name":"Shanghai Sci-Tech Inno Center for Infection &amp; Immunity, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, School of Life Science, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-0175","authenticated-orcid":true,"given":"Youjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China."},{"name":"Department of Clinical Laboratory, Shenzhen Third People\u2019s Hospital, National Clinical Research Center for Infectious Diseases, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518112, China."},{"name":"Zhejiang Provincial Key Laboratory for Microbial Biochemistry and Metabolic Engineering, Zhejiang University, Hangzhou, Zhejiang 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuab003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325753"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110505"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11041118"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.420"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207028109"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.410290"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2359"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2361"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805983105"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22360-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19251-5"},{"key":"e_1_3_2_14_2","first-page":"e02084","article-title":"A canonical biotin synthesis enzyme, 8-amino-7-oxononanoate synthase (BioF), utilizes different acyl chain donors in B. subtilis and E. coli","volume":"84","author":"Manandhar M.","year":"2017","unstructured":"M. Manandhar, J. E. Cronan, A canonical biotin synthesis enzyme, 8-amino-7-oxononanoate synthase (BioF), utilizes different acyl chain donors in B. subtilis and E. coli. Appl. Environ. Microbiol. 84, e02084\u2013e02017 (2017).","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010615"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2019.1706913"},{"key":"e_1_3_2_17_2","unstructured":"O\u2019Neill J. Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. London: Review on Antimicrobial Resistance (2014). https:\/\/amr-review.org\/sites\/default\/files\/AMR Review Paper - Tackling a crisis for the health and wealth of nations_1.p."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlife.2024.04.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.07.057"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.780568"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal1803"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867326666190119161551"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0595-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011110"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00032-21"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01307-5"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01369-z"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01490-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12170"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12817"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14066"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b11895"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.09.003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81262-0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac387"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.112.2.830-839.1972"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.8.2219"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)91866-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.08.028"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444906009474"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.12961"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12030516"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.06.002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000924"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02317-17"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1361"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00177-16"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005957"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00133-19"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0278-1"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900038"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2021.01.007"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15171"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2023.10.038"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1086\/519424"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit675"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1317412"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0899-7"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.05.008"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104428"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0915-1"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00031-10"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12460"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002264"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300748"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1mb05022b"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2011.03.001"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34682-3"},{"key":"e_1_3_2_70_2","article-title":"Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth","volume":"156987","author":"Yadav M. K.","year":"2014","unstructured":"M. K. Yadav, S. W. Park, S. W. Chae, J. Song, Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth. Biomed. Res. Int. 156987, 10.1155\/2014\/156987 (2014).","journal-title":"Biomed. Res. Int."},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2009.J018"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00201"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0288-0"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00704-12"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206411109"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00835-09"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.04.012"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/mra.01441-20"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-145-3-621"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2015.08.019"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90366-J"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20230161"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi061789e"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi9719861"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(97)00169-3"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1014971"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.12.5662-5668.1988"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022807"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80326-3"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.04911804"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444913022750"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444903008126"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-019-01669-w"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh340"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4285"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu300"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab301"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280011"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adp3954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T14:04:14Z","timestamp":1734703454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp3954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":99,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2024,12,20]]}},"alternative-id":["10.1126\/sciadv.adp3954"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adp3954","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"2024-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadp3954"}}