{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:45:45Z","timestamp":1783665945160,"version":"3.55.0"},"reference-count":100,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"47","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,11,22]]},"abstract":"<jats:p>Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson\u2019s disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few well-known genes controlling peripheral iron, remain unclear. We generated scores based on the archetypal brain iron accumulation observed in magnetic resonance imaging scans of individuals with excessive dietary iron absorption and hemochromatosis risk. Genome-wide analysis revealed that this score is highly heritable, identifying loci associated with iron homeostasis, and driven by peripheral iron levels. Our score predicted gait abnormalities and showed a U-shaped relationship with PD risk, identifying individuals with threefold increased risk. These results establish a hormetic relationship between brain iron and PD risk, where central iron levels are strongly determined by genetics via peripheral iron. This framework combining forward and reverse genetics is a powerful study design to understand genomic drivers underlying high dimensional phenotypes.<\/jats:p>","DOI":"10.1126\/sciadv.adp4431","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T14:10:42Z","timestamp":1732284642000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Hemochromatosis neural archetype reveals iron disruption in motor circuits"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4870-4501","authenticated-orcid":true,"given":"Robert","family":"Loughnan","sequence":"first","affiliation":[{"name":"Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA."},{"name":"Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA."},{"name":"Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74103, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ahern","sequence":"additional","affiliation":[{"name":"Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA."},{"name":"Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-6820","authenticated-orcid":true,"given":"Mary","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-9370","authenticated-orcid":true,"given":"Terry L.","family":"Jernigan","sequence":"additional","affiliation":[{"name":"Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA."},{"name":"Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA."},{"name":"Department of Psychiatry, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Department of Radiology, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Donald J.","family":"Hagler","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Department of Radiology, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-9848","authenticated-orcid":true,"given":"John R.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA."},{"name":"Swartz Center for Computational Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-2625","authenticated-orcid":true,"given":"Oleksandr","family":"Frei","sequence":"additional","affiliation":[{"name":"NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7484-0980","authenticated-orcid":true,"given":"Diana M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA."},{"name":"Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Medical Scientist Training Program, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-3568","authenticated-orcid":true,"given":"Ole","family":"Andreassen","sequence":"additional","affiliation":[{"name":"NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-3670","authenticated-orcid":true,"given":"Noah","family":"Zaitlen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-4519","authenticated-orcid":true,"given":"Leo","family":"Sugrue","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging and Department of Psychiatry, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-1976","authenticated-orcid":true,"given":"Wesley K.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74103, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-2966","authenticated-orcid":true,"given":"Anders","family":"Dale","sequence":"additional","affiliation":[{"name":"Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA."},{"name":"Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Department of Radiology, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Department of Neuroscience, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-9335","authenticated-orcid":true,"given":"Andrew J.","family":"Schork","sequence":"additional","affiliation":[{"name":"Institute of Biological Psychiatry, Mental Health Center\u2013Sct Hans, Copenhagen University Hospital, Copenhagen, Denmark."},{"name":"Section for Geogenetics, GLOBE Institute, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-2128","authenticated-orcid":true,"given":"Chun Chieh","family":"Fan","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA."},{"name":"Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74103, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3453"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32594-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00432.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.05.011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01315-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126493"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02399-z"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3982"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081399"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/581256"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"S. J. Hayflick M. A. Kurian P. Hogarth \u201cNeurodegeneration with brain iron accumulation\u201d in Neurogenetics Part I D. H. Geschwind H. L. Paulson C. Klein Eds. (Elsevier 2018) vol. 147 pp. 293\u2013305.","DOI":"10.1016\/B978-0-444-63233-3.00019-1"},{"key":"e_1_3_2_15_2","first-page":"752","article-title":"Iron chelation in movement disorders: Logical or ironical","volume":"48","author":"Kulshreshtha D.","year":"2021","unstructured":"D. Kulshreshtha, J. Ganguly, M. Jog, Iron chelation in movement disorders: Logical or ironical. Can. J. Neurol. Sci. 48, 752\u2013759 (2021).","journal-title":"Can. J. Neurol. Sci."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30142-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209254"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29145"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01074-w"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4501"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.01.014"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.00945.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11607-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k5222"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.2030"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119632"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4269"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2011.07.004"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490310111"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01575-z"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201604057"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.12.007"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.01.026"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0081-4"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8464"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-019-0507-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02317-2"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.40.24395"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0542-z"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36669"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100029140"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb07264.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd80c1"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20826"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","unstructured":"W. Thomas Thach A. J. Bastian \u201cRole of the cerebellum in the control and adaptation of gait in health and disease\u201d in Progress in Brain Research (Elsevier 2004) vol. 143 pp. 353\u2013366; https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079612303430343.","DOI":"10.1016\/S0079-6123(03)43034-3"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130310"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00734.x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7174-x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/13547500600799748"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30320-5"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.027"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112399"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","unstructured":"J. Ahern M. E. Boyle W. K. Thompson C. C. Fan R. Loughnan Dietary and lifestyle factors of brain iron accumulation and Parkinson\u2019s disease risk. medRxiv 24304253 [Preprint] (2024); https:\/\/doi.org\/10.1101\/2024.03.13.24304253.","DOI":"10.1101\/2024.03.13.24304253"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00024"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01145-2"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01221-3"},{"key":"e_1_3_2_61_2","first-page":"7049108","article-title":"Parkinson\u2019s disease: The mitochondria-iron link","volume":"2016","author":"Mu\u00f1oz Y.","year":"2016","unstructured":"Y. Mu\u00f1oz, C. M. Carrasco, J. D. Campos, P. Aguirre, M. T. N\u00fa\u00f1ez, Parkinson\u2019s disease: The mitochondria-iron link. Parkinsons Dis. 2016, 7049108 (2016).","journal-title":"Parkinsons Dis."},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000262033.01945.9a"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10444"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14693-3"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht333"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2015-0065"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320309"},{"key":"e_1_3_2_69_2","unstructured":"R. Prayson Neuropathology (2011)."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071361"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06380-9"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.034"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03205-y"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu704"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21896"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-023-10143-0"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt144"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11258"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.03.001"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116091"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.09.046"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(01)91393-X"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)80004-9"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00870-7"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.4161\/fly.19695"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00092-5"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01016-z"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11181-1"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3404"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14248"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i189"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab186"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.63"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adp4431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T14:12:28Z","timestamp":1732284748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp4431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":100,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2024,11,22]]}},"alternative-id":["10.1126\/sciadv.adp4431"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adp4431","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.10.22.22281386","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,22]]},"assertion":[{"value":"2024-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadp4431"}}