{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:16:10Z","timestamp":1790259370438,"version":"4.1.0"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"40","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,10,4]]},"abstract":"<jats:p>\n                    Disrupted\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification modulates various inflammatory disorders. However, the role of m\n                    <jats:sup>6<\/jats:sup>\n                    A in regulating cutaneous inflammation remains elusive. Here, we reveal that the m\n                    <jats:sup>6<\/jats:sup>\n                    A and its methyltransferase METTL3 are down-regulated in keratinocytes in inflammatory skin diseases. Inducible deletion of\n                    <jats:italic>Mettl3<\/jats:italic>\n                    in murine keratinocytes results in spontaneous skin inflammation and increases susceptibility to cutaneous inflammation with activation of neutrophil recruitment. Therapeutically, restoration of m\n                    <jats:sup>6<\/jats:sup>\n                    A alleviates the disease phenotypes in mice and suppresses inflammation in human biopsy specimens. We support a model in which m\n                    <jats:sup>6<\/jats:sup>\n                    A modification stabilizes the mRNA of the lipid-metabolizing enzyme ELOVL6 via the m\n                    <jats:sup>6<\/jats:sup>\n                    A reader IGF2BP3, leading to a rewiring of fatty acid metabolism with a reduction in palmitic acid accumulation and, consequently, suppressing neutrophil chemotaxis in cutaneous inflammation. Our findings highlight a previously unrecognized epithelial-intrinsic m\n                    <jats:sup>6<\/jats:sup>\n                    A modification\u2013lipid metabolism pathway that is essential for maintaining epidermal and immune homeostasis and lay the basis for potential therapeutic targeting of m\n                    <jats:sup>6<\/jats:sup>\n                    A modulators to attenuate inflammatory skin diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp5332","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T13:58:33Z","timestamp":1727877513000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":25,"title":["<i>N<\/i>\n                    <sup>6<\/sup>\n                    -methyladenosine modification\u2013tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-6424","authenticated-orcid":true,"given":"Lian","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China."},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4998-3099","authenticated-orcid":true,"given":"You","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China."},{"name":"Frontier Science Center for Stem Cell Research, Tongji University, Shanghai, 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Academy of Sciences, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangluyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China."},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhe","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China."},{"name":"Frontier Science Center for Stem Cell Research, Tongji University, Shanghai, 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