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Here, an alternative IME adaptative nitrite reductase\u2013mimicking nanozyme is constructed by in situ growth of ultrasmall copper sulfide clusters on the surface of a nanofibrillar lysozyme assembly (NFLA\/CuS NHs), which can temporally regulate nitric oxide (NO) gradient concentration to kill bacteria initially and promote tissue regeneration subsequently. Benefiting from a copper nitrite reductase (CuNIR)\u2013inspired structure with CuS cluster as active center and NFLA as skeleton, NFLA\/CuS NHs efficiently boost the catalytic reduction of nitrite to NO. The inherent supramolecular fibrillar networks displays excellent bacterial capture capability, facilitating initial high-concentration NO attacks on the bacteria. The subsequent catalytic release of low-concentration NO by NFLA\/CuS NHs\u2013mediated nitrite reduction remarkably promotes cell migration and angiogenesis. This work paves the way for dynamically eliminating MDR bacterial infection and promoting tissue regeneration in a simple and smart way through CuNIR-mimicking catalysis.<\/jats:p>","DOI":"10.1126\/sciadv.adp5935","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T17:59:03Z","timestamp":1725040743000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":56,"title":["Nitrite reductase\u2013mimicking catalysis temporally regulating nitric oxide concentration gradient adaptive for antibacterial therapy"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-5871","authenticated-orcid":true,"given":"Yonghai","family":"Feng","sequence":"first","affiliation":[{"name":"Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu Province, 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