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Global label-free proteomics, innovative assays capturing physiological functions of the fallopian tube (i.e., oocyte transport), and whole-organ single-cell resolution mapping are used to validate these assembloids through a multifaceted platform with direct comparisons to fallopian tube tissue. These techniques converge at a unique combination of assembloid parameters with the highest similarity to the reference fallopian tube. This work establishes (i) an optimized model of the human fallopian tubes for in vitro studies of their pathophysiology and (ii) an iterative platform for customized 3D in vitro models of human organs that are molecularly, functionally, and microanatomically accurate by combining tunable assembloid and tissue mapping methods.<\/jats:p>","DOI":"10.1126\/sciadv.adp6285","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:59:07Z","timestamp":1727445547000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":29,"title":["Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-0113","authenticated-orcid":true,"given":"Ashleigh J.","family":"Crawford","sequence":"first","affiliation":[{"name":"Johns Hopkins Institute for Nanobiotechnology, The 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