{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:22:52Z","timestamp":1791969772960,"version":"4.3.4"},"reference-count":70,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"20","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,5,16]]},"abstract":"<jats:p>\n                    Parkinson\u2019s disease (PD) is the second most common neurodegenerative disease, with a rapidly increasing prevalence worldwide. Biomarkers monitoring state and progression are urgently needed, and metabolomics from easily accessible biofluids holds the potential to elucidate pathophysiological underpinnings in PD. Several studies suggested metabolomic differences between patients and controls, but findings are controversial, and independent replication is scarce. We thus applied state-of-the-art, large-scale metabolomics in patients with idiopathic and monogenic PD and controls from two independent samples, analyzed by a strict meta-analysis approach. Thereby, we (i) debunked that\n                    <jats:sc>l<\/jats:sc>\n                    -Dopa medication and not disease status causes the most substantial metabolomic differences and (ii) identified polyamine metabolism alterations, partly, but not entirely associated with\n                    <jats:sc>l<\/jats:sc>\n                    -Dopa treatment. Furthermore, we found explorative but robust evidence for alterations in endocannabinoid metabolites; detected lipid metabolism alterations, highlighting potential crosslinks with alpha-synuclein pathology; and provided evidence for a metabolomic signature for the role of oxidative damage in patients with\n                    <jats:italic toggle=\"yes\">PRKN<\/jats:italic>\n                    - and\n                    <jats:italic toggle=\"yes\">PINK1<\/jats:italic>\n                    -linked PD.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp7063","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:59:43Z","timestamp":1747231183000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["The role of dopaminergic medication and specific pathway alterations in idiopathic and\n                    <i>PRKN\/PINK1<\/i>\n                    -mediated Parkinson\u2019s disease"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-0282","authenticated-orcid":true,"given":"Alexander","family":"Balck","sequence":"first","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany."},{"name":"Department of Neurology, University of L\u00fcbeck and University Hospital Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-5986","authenticated-orcid":true,"given":"Max","family":"Borsche","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany."},{"name":"Department of Neurology, University of L\u00fcbeck and University Hospital Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-9256","authenticated-orcid":true,"given":"Philip","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Luo","sequence":"additional","affiliation":[{"name":"Digital Twin Center, School of Medicine, University of Galway, University Rd, Galway, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5155-2898","authenticated-orcid":true,"given":"John","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, 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