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In the present work, nitric oxide synthase (NOS)\u2013engineered\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    strain MG1655 (NOBac) was used to hybridize with the sonopiezocatalytic BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    nanoparticles (BTO NPs) for efficient tumor-targeted accumulation and antitumor therapy. Under ultrasound irradiation, superoxide anions created by the piezocatalytic reaction of BTO NPs could immediately react with nitric oxide (NO) generated from NOBac to produce highly oxidative peroxynitrite ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    species in cascade, resulting in robust tumor piezocatalytic therapeutic efficacy, prompting prominent and sustained antitumoral immunoactivation simultaneously. The present work presents a promising cancer immunotherapy based on the engineered and hybridized microbes for highly selective and sonopiezo-controllable tumor catalytic therapy.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp7540","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:58:32Z","timestamp":1730296712000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":33,"title":["Hybridized and engineered microbe for catalytic generation of peroxynitrite and cancer immunotherapy under sonopiezo initiation"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5683-9043","authenticated-orcid":true,"given":"Liping","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences; Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medicine Science, Shanghai, 200050, P. 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