{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:34Z","timestamp":1791895594037,"version":"4.3.4"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"39","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,9,27]]},"abstract":"<jats:p>\n            Alcohol use disorder is highly prevalent worldwide, with characteristically severe pain sensitivity during withdrawal. Here, we established a mouse model of hyperalgesia during ethanol withdrawal (EW) before addiction to investigate the window for onset and underlying mechanisms. Viral tracing with in vivo microendoscopic and two-photon calcium imaging identified a circuit pathway from dorsal hippocampal CA1 glutamatergic neurons (dCA1\n            <jats:sup>Glu<\/jats:sup>\n            ) to anterior cingulate cortex glutamatergic neurons (ACC\n            <jats:sup>Glu<\/jats:sup>\n            ) activated in EW mice with hyperalgesia. Chemogenetic inhibition of this pathway can alleviate hyperalgesia in EW mice, whereas artificial activation recapitulates EW-induced hyperalgesia in na\u00efve mice. These findings demonstrate that the dCA1\n            <jats:sup>Glu<\/jats:sup>\n            \u2192 ACC\n            <jats:sup>Glu<\/jats:sup>\n            neuronal pathway participates in driving EW-induced hyperalgesia before ethanol dependence in mice.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adp8636","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T17:59:07Z","timestamp":1727459947000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["A neural circuit for alcohol withdrawal\u2013induced hyperalgesia in a nondependent state"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-9469","authenticated-orcid":true,"given":"Xin-Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."},{"name":"Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College, Wuhu 241002, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-6153","authenticated-orcid":true,"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College, Wuhu 241002, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-1747","authenticated-orcid":true,"given":"Hong-Rui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-6686","authenticated-orcid":true,"given":"Yanli","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-3181","authenticated-orcid":true,"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."},{"name":"Department of Biophysics and Neurobiology, CAS Key laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230026, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongquan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College, Wuhu 241002, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9644-6458","authenticated-orcid":true,"given":"Yan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Neurobiology, CAS Key laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230026, China."},{"name":"Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26176"},{"key":"e_1_3_2_3_2","first-page":"e19764","article-title":"A clinical overview of acute and chronic pancreatitis: The medical and surgical management","volume":"13","author":"Ashraf H.","year":"2021","unstructured":"H. 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