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TPA2PyBu could provide imaging specificity that differentiates bacterial infection from inflammation and cancer. High in vivo treatment efficacy of TPA2PyBu was achieved in methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    infection mouse models. This promising antimicrobial agent suggests that combining multiple mechanisms of action into a single molecule can be an effective approach to address challenging bacterial infections.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adp9448","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T13:59:46Z","timestamp":1744379986000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["A dual-mechanism luminescent antibiotic for bacterial infection identification and eradication"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-2922","authenticated-orcid":true,"given":"Guobin","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4998-6893","authenticated-orcid":true,"given":"Xianglong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore."},{"name":"Joint School of the National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-8970","authenticated-orcid":true,"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510515, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore."},{"name":"Joint School of the National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6833-8196","authenticated-orcid":true,"given":"Leilei","family":"Shi","sequence":"additional","affiliation":[{"name":"Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0956-2777","authenticated-orcid":true,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore."},{"name":"Joint School of the National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China."},{"name":"Institute for Functional Intelligent Materials, National University of Singapore (Singapore), Blk S9, Level 9, 4 Science Drive 2, Singapore 117544, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41579-018-0125-x","article-title":"The cost of antimicrobial resistance","volume":"17","author":"Hofer U.","year":"2019","unstructured":"U. 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