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We demonstrate here that the addition of nitrate to pyrophosphate-chelated Sn(II)\n            <jats:sub>(aq)<\/jats:sub>\n            suppresses Sn(II) oxidation in water across a broad pH range. Evidence of hydroxyl radical concentration reduction and detection of a radical nitrogen species that only forms in the presence of chelated Sn(II) point to a radical-based reaction mechanism. While this chemistry can be broadly applied, we present that this approach maintains Sn(II)\u2019s antibacterial and anti-inflammatory efficacies as an example of sustained oral chemotherapeutic functionality.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adq0839","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T17:58:33Z","timestamp":1727891913000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Oxidative stability of chelated Sn(II)\n            <sub>(aq)<\/sub>\n            at neutral pH: The critical role of NO\n            <sub>3<\/sub>\n            <sup>\u2212<\/sup>\n            ions"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-9837","authenticated-orcid":true,"given":"Shaoyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5817-1923","authenticated-orcid":true,"given":"Gokul V.","family":"Govindaraju","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Yuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-5489","authenticated-orcid":true,"given":"Carlo Amorin","family":"Daep","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-3376","authenticated-orcid":true,"given":"Cristina","family":"Castro","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5552-0765","authenticated-orcid":true,"given":"Patrick S.","family":"Corrigan","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Masters","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-4040","authenticated-orcid":true,"given":"Long","family":"Pan","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7231-647X","authenticated-orcid":true,"given":"Tatiana V.","family":"Brinzari","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7373-3995","authenticated-orcid":true,"given":"Carl P.","family":"Myers","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive, 909 River Road, Piscataway, NJ 08855, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(89)80028-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma010986c"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma14185254"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2020.109129"},{"key":"e_1_3_2_6_2","first-page":"2479","article-title":"The stannous complex of succinimide as multifunctional additive for lubricating oils","volume":"535","author":"Shi Y. 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