{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:07:11Z","timestamp":1791230831022,"version":"4.1.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"26","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,6,27]]},"abstract":"<jats:p>\n            Low- and middle-income countries face substantial challenges in immunizing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including high costs, limited access, and insufficient local manufacturing. To address these issues, we developed and locally manufactured the AVX\/COVID-12 vaccine using a cost-effective Newcastle disease virus LaSota platform to express a stabilized SARS-CoV-2 spike protein (HexaPro-S). We evaluated the AVX\/COVID-12 vaccine in a phase 2\/3 parallel-group, double-blind, active-controlled, noninferiority trial with 4056 volunteers, demonstrating its safety, good tolerability, and ability to induce neutralizing antibodies against ancestral SARS-CoV-2 and the Omicron BA.2 and BA.5 variants. It also stimulated interferon-\u03b3\u2013producing CD8\n            <jats:sup>+<\/jats:sup>\n            T cells and met the World Health Organization\u2019s noninferiority criteria compared to AZ\/ChAdOx-1-S. No vaccinated participants experienced severe disease, hospitalization, or death. These findings support the use of AVX\/COVID-12 as a booster to help achieve and maintain population immunity while addressing global inequities in vaccine distribution, and it has been approved for adult booster use in Mexico.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adq2887","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T21:26:20Z","timestamp":1753478780000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Phase 2\/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX\/COVID-12 vaccine"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-492X","authenticated-orcid":true,"given":"Constantino","family":"L\u00f3pez-Mac\u00edas","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico (CDMX), M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-9407","authenticated-orcid":true,"given":"Martha","family":"Torres","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda de la Tuberculosis, Instituto Nacional de Enfermedades Respiratorias (INER) \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8894-2413","authenticated-orcid":true,"given":"Brenda","family":"Armenta-Copca","sequence":"additional","affiliation":[{"name":"iLS Clinical Research S.C., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-6704","authenticated-orcid":true,"given":"Niels H.","family":"Wacher","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-1160","authenticated-orcid":true,"given":"Arturo","family":"Galindo-Fraga","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n (INCMNSZ), CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1461-5593","authenticated-orcid":true,"given":"Laura","family":"Castro-Castrezana","sequence":"additional","affiliation":[{"name":"CAIMED Investigaci\u00f3n en Salud S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0212-136X","authenticated-orcid":true,"given":"Andrea Alicia","family":"Colli-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Oaxaca Site Management Organization (OSMO) S.C., Oaxaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-5748","authenticated-orcid":true,"given":"Edgar","family":"Cervantes-Trujano","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cl\u00ednica Acelerada (CICA) S.C., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Erika","family":"Rucker-Joerg","sequence":"additional","affiliation":[{"name":"Clinical Research Institute (CRI) S.C., Edo. de M\u00e9xico, Tlalnepantla, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-1339","authenticated-orcid":true,"given":"Fernando","family":"Lozano-Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cl\u00ednica Chapultepec, CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9297-9139","authenticated-orcid":true,"given":"Juan Jos\u00e9","family":"Rivera-Alcocer","sequence":"additional","affiliation":[{"name":"Unidad de Atenci\u00f3n M\u00e9dica e Investigaci\u00f3n en Salud (UNAMIS), M\u00e9rida, Yucat\u00e1n, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-7792","authenticated-orcid":true,"given":"Abraham","family":"Sim\u00f3n-Campos","sequence":"additional","affiliation":[{"name":"K\u00f6hler &amp; Milstein Research (K&amp;M) Facultad de Medicina, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Yucat\u00e1n, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-2541","authenticated-orcid":true,"given":"Efr\u00e9n Alberto","family":"S\u00e1nchez-Campos","sequence":"additional","affiliation":[{"name":"Centro Multidisciplinario para el Desarrollo Especializado de la Investigaci\u00f3n Cl\u00ednica en Yucat\u00e1n (CEMDEICY) S.C., M\u00e9rida, Yucat\u00e1n, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7834-743X","authenticated-orcid":true,"given":"Rafael","family":"Aguirre-Rivero","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cl\u00ednica del Pacifico (CICPA), Acapulco, Guerrero, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-4141","authenticated-orcid":true,"given":"Alejandro Jos\u00e9","family":"Mu\u00f1iz-Carvajal","sequence":"additional","affiliation":[{"name":"Red OSMO, Centro de Investigaci\u00f3n y Avances M\u00e9dicos Especializados (CIAME), Canc\u00fan, Quintana Roo, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-5744","authenticated-orcid":true,"given":"Luis","family":"del Carpio-Orantes","sequence":"additional","affiliation":[{"name":"Instituto Veracruzano de Investigaci\u00f3n Cl\u00ednica (IVIC) S.C., Veracruz, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6419-2140","authenticated-orcid":true,"given":"Francisco","family":"M\u00e1rquez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Hospital de Cardiolog\u00eda de Aguascalientes, Aguascalientes, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Rivera-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico (CDMX), M\u00e9xico."},{"name":"Investigadores por M\u00e9xico, Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT), CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-6692","authenticated-orcid":true,"given":"Alejandro","family":"Torres-Flores","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico (CDMX), M\u00e9xico."},{"name":"Posgrado en Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-5721","authenticated-orcid":true,"given":"Luis","family":"Ram\u00edrez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-9271","authenticated-orcid":true,"given":"Georgina Paz-De","family":"la Rosa","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5334-8803","authenticated-orcid":true,"given":"Oscar","family":"Rojas-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0723-8145","authenticated-orcid":true,"given":"Alejandro","family":"Su\u00e1rez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-8455","authenticated-orcid":true,"given":"Gustavo","family":"Peralta-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6226-6056","authenticated-orcid":true,"given":"Claudia","family":"Carranza","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda de la Tuberculosis, Instituto Nacional de Enfermedades Respiratorias (INER) \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-004X","authenticated-orcid":true,"given":"Esmeralda","family":"Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n en Microbiolog\u00eda, INER \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-2881","authenticated-orcid":true,"given":"Horacio","family":"Zamudio-Meza","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda de la Tuberculosis, Instituto Nacional de Enfermedades Respiratorias (INER) \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-4138","authenticated-orcid":true,"given":"Laura E.","family":"Carreto-Binaghi","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda de la Tuberculosis, Instituto Nacional de Enfermedades Respiratorias (INER) \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-2952","authenticated-orcid":true,"given":"Mercedes","family":"Viettri","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda de la Tuberculosis, Instituto Nacional de Enfermedades Respiratorias (INER) \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-0279","authenticated-orcid":true,"given":"Damaris","family":"Romero-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Citometr\u00eda, INER \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3264-3785","authenticated-orcid":true,"given":"Andrea","family":"Palencia","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda de la Tuberculosis, Instituto Nacional de Enfermedades Respiratorias (INER) \u201cIsmael Cos\u00edo Villegas,\u201d CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6558-6316","authenticated-orcid":true,"given":"David","family":"Sarfati-Mizrahi","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-5047","authenticated-orcid":true,"given":"Weina","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2786-4724","authenticated-orcid":true,"given":"H\u00e9ctor El\u00edas","family":"Chagoya-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Consultora Mextrategy S.A.S. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipa","family":"Castro-Peralta","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0337-5823","authenticated-orcid":true,"given":"Peter","family":"Palese","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-776X","authenticated-orcid":true,"given":"Florian","family":"Krammer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-1827","authenticated-orcid":true,"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6430-7080","authenticated-orcid":true,"given":"Bernardo","family":"Lozano-Dubernard","sequence":"additional","affiliation":[{"name":"Laboratorio Avi-Mex S.A. de C.V., CDMX, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"WHO COVID-19 dashboard https:\/\/covid19.who.int\/."},{"key":"e_1_3_2_3_2","unstructured":"COVID-19 pandemic https:\/\/ourworldindata.org\/coronavirus."},{"key":"e_1_3_2_4_2","unstructured":"COVID19 vaccine tracker https:\/\/covid19.trackvaccines.org\/."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9060582"},{"key":"e_1_3_2_6_2","unstructured":"Global dashboard for vaccine equity 18 April 2021; https:\/\/data.undp.org\/vaccine-equity\/."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050498"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0826"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"S. K. Samal \u201cNewcastle disease virus \u201d in Avian Virology-Current Research and Future Trends. S. K. Samal Ed. (Caister Academic Press ed. 1 2019) pp. 43\u201385.","DOI":"10.21775\/9781912530106.02"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703584104"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-3119(17)61660-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30356-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602566103"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9080619"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26499-y"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102941"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01908-21"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00662-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"C. L\u00f3pez-Mac\u00edas M. Torres B. Armenta-Copca N. Wacher L. Castro-Castrezana A. A. Colli-Dom\u00ednguez T. Rivera-Hern\u00e1ndez A. Torres-Flores L. Ram\u00edrez-Mart\u00ednez G. P.-D. la Rosa O. Rojas-Mart\u00ednez A. Su\u00e1rez-Mart\u00ednez G. Peralta-S\u00e1nchez C. Carranza E. Ju\u00e1rez H. Zamudio-Meza L. E. Carreto-Binaghi M. Viettri D. Romero-Rodr\u00edguez A. Palencia E. Reyna-Rosas J. E. M\u00e1rquez-Garc\u00eda D. Sarfati-Mizrahi W. Sun H. E. Chagoya-Cort\u00e9s F. Castro-Peralta P. Palese F. Krammer A. Garc\u00eda-Sastre B. Lozano-Dubernard A phase II study integrating a single-blind safety phase with a double-blind placebo-controlled randomized phase assessing single-dose intramuscular or intranasal administration to evaluate the safety and immunogenicity of the recombinant vaccine against COVID-19 (AVX\/COVID-12 \u201cPatria\u201d) based on an active Newcastle disease viral vector as a heterologous booster in subjects with evidence of previous immunity to SARS-CoV-2. medRxiv 2024.02.11.24302594 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.02.11.24302594.","DOI":"10.1101\/2024.02.11.24302594"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.04.078"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101323"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"P. Pitisuttithum V. Luvira S. Lawpoolsri S. Muangnoicharoen S. Kamolratanakul C. Sivakorn P. Narakorn S. Surichan S. Prangpratanporn S. Puksuriwong S. Lamola L. D. Mercer R. Raghunandan W. Sun Y. Liu J. M. Carre\u00f1o R. Scharf W. Phumratanaprapin F. Amanat L. Gagnon C.-L. Hsieh R. Kaweepornpoj S. Khan M. Lal S. McCroskery J. McLellan I. Mena M. Meseck B. Phonrat Y. Sabmee R. Singchareon S. Slamanig N. Suthepakul J. Tcheou N. Thantamnu S. Theerasurakarn S. Tran T. Vilasmongkolchai J. A. White A. Garcia-Sastre P. Palese F. Krammer K. Poopipatpol P. Wirachwong R. Hjorth B. L. Innis Safety and immunogenicity of an inactivated recombinant Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomised placebo-controlled phase 1\/2 trial. medRxiv 2021.09.17.21263758 [Preprint] (2021). https:\/\/doi.org\/10.1101\/2021.09.17.21263758.","DOI":"10.1016\/j.eclinm.2022.101323"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11050985"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100675"},{"key":"e_1_3_2_25_2","unstructured":"\u201cTracking coronavirus vaccinations around the world \u201d New York Times 13 March 2023; www.nytimes.com\/interactive\/2021\/world\/covid-vaccinations-tracker.html."},{"key":"e_1_3_2_26_2","unstructured":"N\u00famero de dosis compradas de vacunas contra COVID-19 en M\u00e9xico a 25 de noviembre de 2021 por tipo de vacuna https:\/\/es.statista.com\/estadisticas\/1207394\/dosis-confirmadas-vacunas-covid-mexico\/. [Number of COVID-19 vaccine doses purchased in Mexico as of November 25 2021 by vaccine type.]"},{"key":"e_1_3_2_27_2","unstructured":"Guidelines on clinical evaluation of vaccines: Regulatory expectations annex 1 TRS no 924 www.who.int\/publications\/m\/item\/guidelines-on-clinical-evaluation-of-vaccines-regulatory-expectations."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03841-4"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl5344"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1026473"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","unstructured":"A. Frei M. Kaufmann R. Amati A. B. Dettwiler V. von Wyl A. M. Annoni C. Pellaton G. Pantaleo J. S. Fehr V. D\u2019Acremont M. Bochud E. Albanese M. A. Puhan C. I. R. Group Development of hybrid immunity during a period of high incidence of infections with Omicron subvariants: A prospective population based multi-region cohort study. medRxiv 2022.10.14.22281076 [Preprint] (2022). https:\/\/doi.org\/10.1101\/2022.10.14.22281076.","DOI":"10.1101\/2022.10.14.22281076"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40592-4"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade6132"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32661-1"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35168-7"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2906.230130"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4053"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.011"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00094-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105479"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203965"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01700-x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo2202"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0245"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2022.10.007"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10040578"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30222-w"},{"key":"e_1_3_2_48_2","unstructured":"The Government Pharmaceutical Organization (GPO) Thailand; https:\/\/www.gpo.or.th\/post\/x4ql6u9g-173073."},{"key":"e_1_3_2_49_2","unstructured":"Comit\u00e9 de Mol\u00e9culas Nuevas de Cofepris emite opini\u00f3n favorable a vacuna Patria contra COVID-19 www.gob.mx\/cofepris\/articulos\/comite-de-moleculas-nuevas-de-cofepris-emite-opinion-favorable-a-vacuna-patria-contra-covid-19. [New Molecules Committee of the Federal Commission for the Protection against Sanitary Risks (COFEPRIS) issues favorable opinion on Patria COVID-19 vaccine | Government of Mexico.]"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adq2887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T21:26:28Z","timestamp":1753478788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adq2887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":48,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,6,27]]}},"alternative-id":["10.1126\/sciadv.adq2887"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adq2887","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadq2887"}}