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Here, we report the high-pressure synthesis of a metastable nonsymmetrical dicopper-\u03bc-oxo compound with exceptional reactivity toward the mono-oxygenation of aliphatic C\u2500H bonds. The nonequivalent coordination environment of copper stabilizes localized mixed valency and greatly enhances the hydrogen atom abstraction activity of the bridging oxygen, enabling room-temperature hydroxylation of methane under pressure. These findings highlight the role of dissymmetry in the reactivity of binuclear copper centers and demonstrate precise control of molecular structures by mechanical means.<\/jats:p>","DOI":"10.1126\/sciadv.adq3366","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T13:58:42Z","timestamp":1728050322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["High pressure\u2013derived nonsymmetrical [Cu\n                    <sub>2<\/sub>\n                    O]\n                    <sup>2+<\/sup>\n                    core for room-temperature methane hydroxylation"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1360-579X","authenticated-orcid":true,"given":"Peter E.","family":"VanNatta","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of North Texas, Denton, TX 76205, 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