{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:42:31Z","timestamp":1790566951488,"version":"4.1.0"},"reference-count":66,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:p>We know more about the costs of chronic stress than the benefits of the acute stress response\u2014an adaptive response that buffers organisms from life-threatening challenges. As yet, no primate study has empirically identified how the stress response adaptively affects evolutionary fitness. Here, we take advantage of a natural experiment\u2014an El Ni\u00f1o drought\u2014that produced unprecedented mortality for wild white-faced capuchins. Using a reaction norm approach, we provide evidence from primates that a more robust stress response to a challenge, measured using fecal glucocorticoids, predicts a greater likelihood of survival. We show that individuals with greater stress responsiveness to previous droughts later had higher survival across a severe El Ni\u00f1o drought. Evolutionary models need empirical data on how stress responsivity varies in adaptive ways. While we cannot buffer subjects from catastrophic events, we can use them to understand which aspects of the stress response help animals to \u201cweather the storm.\u201d<\/jats:p>","DOI":"10.1126\/sciadv.adq5020","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T18:58:39Z","timestamp":1737572319000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Stress responsiveness in a wild primate predicts survival across an extreme El Ni\u00f1o drought"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-3777","authenticated-orcid":true,"given":"Sofia C.","family":"Carrera","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-226X","authenticated-orcid":true,"given":"Irene","family":"Godoy","sequence":"additional","affiliation":[{"name":"Lomas Barbudal Monkey Project, Lomas Barbudal Biological Reserve, Bagaces, Costa Rica."},{"name":"Department of Animal Behaviour, University of Bielefeld, Bielefeld 33501, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-2757","authenticated-orcid":true,"given":"Colleen M.","family":"Gault","sequence":"additional","affiliation":[{"name":"Lomas Barbudal Monkey Project, Lomas Barbudal Biological Reserve, Bagaces, Costa Rica."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-4172","authenticated-orcid":true,"given":"Ashley","family":"Mensing","sequence":"additional","affiliation":[{"name":"Lomas Barbudal Monkey Project, Lomas Barbudal Biological Reserve, Bagaces, Costa Rica."},{"name":"Department of Anthropology, University of California, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5724-2934","authenticated-orcid":true,"given":"Juliane","family":"Damm","sequence":"additional","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-5383","authenticated-orcid":true,"given":"Susan E.","family":"Perry","sequence":"additional","affiliation":[{"name":"Lomas Barbudal Monkey Project, Lomas Barbudal Biological Reserve, Bagaces, Costa Rica."},{"name":"Department of Anthropology, University of California, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-6872","authenticated-orcid":true,"given":"Jacinta C.","family":"Beehner","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA."},{"name":"Department of Anthropology, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/138032a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2019.113355"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00073"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440400111013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.08.019"},{"key":"e_1_3_2_7_2","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky R. M.","year":"2000","unstructured":"R. M. Sapolsky, L. M. Romero, A. U. Munck, How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21, 55\u201389 (2000).","journal-title":"Endocr. Rev."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00746-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2008.05.017"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.12.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3932"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf6759"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2017.03.003"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113611"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2004.0245"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icab196"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icy046"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2014.04.016"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-9326\/aaacbc"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2459"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(02)00146-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2022.114109"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.23096"},{"key":"e_1_3_2_24_2","first-page":"3157","article-title":"Stress physiology as a predictor of survival in Galapagos marine iguanas","volume":"277","author":"Romero L. M.","year":"2010","unstructured":"L. M. Romero, M. Wikelski, Stress physiology as a predictor of survival in Galapagos marine iguanas. Proc. Biol. Sci. 277, 3157\u20133162 (2010).","journal-title":"Proc. Biol. Sci."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0908-8857.2006.03733.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3354\/meps10618"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)00287-S"},{"key":"e_1_3_2_28_2","unstructured":"L. Michael Romero J. C. Wingfield Tempests Poxes Predators and People: Stress in Wild Animals and How They Cope (Oxford Univ. Press 2015)."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010632118"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-018-0256-0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2012.01668.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1086\/648604"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2020.09.003"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100320"},{"key":"e_1_3_2_35_2","first-page":"1","article-title":"Stress and the HPA axis: Clinical assessment and therapeutic considerations","volume":"9","author":"Thomas G. G.","year":"2010","unstructured":"G. G. Thomas, C. Le, Stress and the HPA axis: Clinical assessment and therapeutic considerations. Standard 9, 1\u201312 (2010).","journal-title":"Standard"},{"key":"e_1_3_2_36_2","first-page":"20161887","article-title":"How can we estimate natural selection on endocrine traits? Lessons from evolutionary biology","volume":"283","author":"Bonier F.","year":"2016","unstructured":"F. Bonier, P. R. Martin, How can we estimate natural selection on endocrine traits? Lessons from evolutionary biology. Proc. Biol. Sci. 283, 20161887 (2016).","journal-title":"Proc. Biol. Sci."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22229"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icx064"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.1005"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.asb.2016.01.002"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/681016"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.016"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579401003029"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.131091498"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2017.10.015"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.04.027"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocon.2015.03.017"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06544-0"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06236-9"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","unstructured":"S. Perry J. H. Manson Manipulative Monkeys: The Capuchins of Lomas Barbudal (Harvard Univ. Press 2008).","DOI":"10.4159\/9780674042049"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.2307\/2388320"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","unstructured":"G. W. Frankie A. Mata S. Bradleigh Vinson Biodiversity Conservation in Costa Rica: Learning the Lessons in a Seasonal Dry Forest (University of California Press 2004).","DOI":"10.1525\/9780520937772"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1163\/156853909X404420"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","unstructured":"S. Perry \u201cChapter 4 - The behavior of wild white-faced capuchins: Demography life history social relationships and communication\u201d in Advances in the Study of Behavior H. J. Brockmann T. J. Roper M. Naguib J. C. Mitani L. W. Simmons Eds. (Academic Press 2012) vol. 44 pp. 135\u2013181.","DOI":"10.1016\/B978-0-12-394288-3.00004-6"},{"key":"e_1_3_2_56_2","unstructured":"R Core Team R: A Language and Environment for Statistical Computing. (R Foundation for Statistical Computing Vienna Austria 2023); https:\/\/www.R-project.org\/."},{"key":"e_1_3_2_57_2","unstructured":"T. B. McKee N. J. Doesken J. Kleist \u201cThe relationship of drought frequency and duration to time scales\u201d in Proceedings of the 8th Conference on Applied Climatology (Boston 1993) vol. 17 pp. 179\u2013183."},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.2307\/2387740"},{"key":"e_1_3_2_59_2","unstructured":"National Integrated Drought Information System \u201cMonitoring drought\u201d. https:\/\/www.drought.gov\/what-is-drought\/monitoring-drought."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20954"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00265-016-2168-1"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2018-017"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-019-01858-z"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.122"},{"key":"e_1_3_2_65_2","unstructured":"D. N. Karger S. Lange C. Hari C. P. O. Reyer N. E. Zimmermann CHELSA-W5E5 v1.1: W5E5 v1.0 downscaled with CHELSA v2.0 (ISIMIP Repository 2023); https:\/\/doi.org\/10.48364\/ISIMIP.836809.1."},{"key":"e_1_3_2_66_2","unstructured":"W. Maetens standaRdized: R package for the calculation of standardized index values (SPI SPEI SSI \u2026) on a daily basis (Github); https:\/\/github.com\/WillemMaetens\/standaRdized."},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/joc.1371"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adq5020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T18:59:58Z","timestamp":1737572398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adq5020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,1,24]]}},"alternative-id":["10.1126\/sciadv.adq5020"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adq5020","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"2024-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadq5020"}}