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Here, we characterize PCE rats during food or opioid-maintained reward seeking. We find that the supramotivational phenotype of PCE rats is independent of value-based processing and is instead related to augmented reinforcing efficiency of opioid rewards. Our findings reveal that prenatal THC exposure leads to increased cue-evoked dopamine responses and an overrepresentation of effort-driven striatal encoding patterns. Recapitulating clinical findings, drug-related PCE adaptations were more pronounced in males, who showed increased vulnerability for relapse. Collectively, these findings indicate that prenatal THC exposure in male rats engenders a pronounced neurodevelopmental susceptibility to addiction-like disorders.<\/jats:p>","DOI":"10.1126\/sciadv.adq5652","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T14:00:47Z","timestamp":1731074447000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Dynamic overrepresentation of accumbal cues in food- and opioid-seeking rats after prenatal THC exposure"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-1764","authenticated-orcid":true,"given":"Miguel \u00c1.","family":"Luj\u00e1n","sequence":"first","affiliation":[{"name":"Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-4750","authenticated-orcid":true,"given":"Reana","family":"Young-Morrison","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-8784","authenticated-orcid":true,"given":"Sonia","family":"Aroni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-3330","authenticated-orcid":true,"given":"Istv\u00e1n","family":"Katona","sequence":"additional","affiliation":[{"name":"Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary."},{"name":"Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-8651","authenticated-orcid":true,"given":"Miriam","family":"Melis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Cheer","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA."},{"name":"Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17225"},{"key":"e_1_3_2_3_2","first-page":"153","article-title":"Umbilical cord collection and drug testing to estimate prenatal substance exposure in Utah","volume":"140","author":"Smid M. 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