{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:38:50Z","timestamp":1789090730968,"version":"build-2803163510"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,1,3]]},"abstract":"<jats:p>\n            The NOD-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in human acute and chronic liver diseases. However, the role and cell-specific contribution of NLRP3 in liver regeneration remains unclear. Here, we found that NLRP3 was highly activated during the early stage of liver regeneration via 70% partial hepatectomy (PHx) mice model and clinical data. Global NLRP3 depletion or pharmacologically blocking NLRP3 significantly enhanced liver regeneration, while NLRP3 overexpression impaired it after PHx. Furthermore, mice with myeloid-specific knockout of\n            <jats:italic>Nlrp3<\/jats:italic>\n            (\n            <jats:italic>Nlrp3<\/jats:italic>\n            <jats:sup>\n              \u0394\n              <jats:italic>mye<\/jats:italic>\n            <\/jats:sup>\n            ), rather than hepatocyte-specific knockout (\n            <jats:italic>Nlrp3<\/jats:italic>\n            <jats:sup>\n              \u0394\n              <jats:italic>hep<\/jats:italic>\n            <\/jats:sup>\n            ), showed improved liver regeneration compared to control (\n            <jats:italic>\n              Nlrp3\n              <jats:sup>fl\/fl<\/jats:sup>\n            <\/jats:italic>\n            ). Mechanistically, deficiency of\n            <jats:italic>Nlrp3<\/jats:italic>\n            promoted myeloid-epithelial-reproductive tyrosine kinase (MerTK)\u2013mediated efferocytosis, thereby inducing macrophages toward a pro-reparative Ly6C\n            <jats:sup>lo<\/jats:sup>\n            phenotype. Notably, NLRP3 inhibition by MCC950 effectively reversed the impairment of liver regeneration after PHx in mice fed a high-fat diet. Our findings provide a potential therapeutic strategy for the prevention and treatment of post-hepatectomy liver failure.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adq5786","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T19:03:34Z","timestamp":1735758214000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":23,"title":["NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-7347","authenticated-orcid":true,"given":"Susu","family":"Wei","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China."},{"name":"Qilu Zhongke Academy of Modern Microbiology Technology, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-3338","authenticated-orcid":true,"given":"Ge","family":"Guan","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-0979","authenticated-orcid":true,"given":"Xiaoyu","family":"Luan","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2350-6493","authenticated-orcid":true,"given":"Chaoqun","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6150-2939","authenticated-orcid":true,"given":"Longyu","family":"Miao","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-3813","authenticated-orcid":true,"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China."},{"name":"Institute of Stem Cell and Regenerative Medicine, School of Basic Medicine, Qingdao University, Qingdao, 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