{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:08:58Z","timestamp":1793797738210,"version":"4.6.1"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"44","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Osteoporotic bone defects refer to the disruption of bone structural integrity in patients with osteoporosis and pose a substantial challenge to orthopedic surgeons. In this study, we developed a biomimetic hydrogel to improve the osteogenic microenvironment and promote stem cell homing. This hydrogel served as a container for S-nitrosoglutathione and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , promoting the release of bioactive nitric oxide (NO) from bone marrow mesenchymal stem cells (BMSCs) and human vascular endothelial cells and activating the NO\/cyclic guanosine monophosphate signaling pathway. These changes promote osteogenic and angiogenic couplings. The hydrogel simultaneously recruited BMSCs by conjugating the stem cell homing peptide SKPPGTSS. Using a rat distal femoral defect model, it was demonstrated that this hydrogel can effectively increase the formation of bone tissue and new blood vessels and has immune-regulating functions. We envision that this hydrogel may be a minimally invasive yet highly effective strategy for expediting the healing of osteoporotic bone defects.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adq6700","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T13:59:14Z","timestamp":1730469554000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":85,"title":["Stem cell\u2013homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-5386","authenticated-orcid":true,"given":"Fei-Long","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."},{"name":"Department of Orthopaedics, General Hospital of Central Theater Command (Wuhan General Hospital of Guangzhou Command, previously), Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0855-2726","authenticated-orcid":true,"given":"Yuan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Basic Medical College, Fourth Military Medical University, Xi'an 710032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-220X","authenticated-orcid":true,"given":"Tian-Fu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-555X","authenticated-orcid":true,"given":"Chao-Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-6507","authenticated-orcid":true,"given":"Kuo","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1747-9807","authenticated-orcid":true,"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-1839","authenticated-orcid":true,"given":"Ming-Rui","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-5333","authenticated-orcid":true,"given":"Xiao-Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-1008","authenticated-orcid":true,"given":"Quan-You","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0932-4568","authenticated-orcid":true,"given":"Zheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-8828","authenticated-orcid":true,"given":"Ji-Xian","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-2083","authenticated-orcid":true,"given":"Cheng-Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1513724"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c02147"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181cec4a1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703438"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200314"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13145"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.01.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.12.026"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0570-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110981"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15246g"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301352"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101107"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00241"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305442"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200802009"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c01052"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/b907478c"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4489"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-6-1030"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk0011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02927-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119300"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2791"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22017"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2732"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12794"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-021-09824-3"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02646-5"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006598"},{"key":"e_1_3_2_35_2","first-page":"19","article-title":"Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice","volume":"77","author":"Liu V.","year":"2008","unstructured":"V. Liu, P. Huang, Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice. Cardiovasc. Res. 77, 19\u201329 (2008).","journal-title":"Cardiovasc. Res."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.045"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm049"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202916109"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03348"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000310"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.018"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32912-x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/acab36"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17259"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01012J"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.039"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2019.112721"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12964"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC00600A"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adq6700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T13:59:22Z","timestamp":1730469562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adq6700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":48,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1126\/sciadv.adq6700"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adq6700","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadq6700"}}