{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:20:50Z","timestamp":1784082050138,"version":"3.55.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,1,10]]},"abstract":"<jats:p>\n                    The fertile gonad includes cells of two distinct developmental origins: the somatic mesoderm and the germ line. How somatic and germ cells interact to develop and maintain fertility is not well understood. Here, using grafting experiments and transgenic reporter animals, we find that a specific part of the gonad\u2014the germinal zone\u2014acts as a sexual organizer to induce and maintain de novo germ cells and somatic gonads in the cnidarian\n                    <jats:italic>Hydractinia symbiolongicarpus<\/jats:italic>\n                    . Germ cells express a member of the transforming growth factor\u2013\u03b2 family,\n                    <jats:italic>Gonadless<\/jats:italic>\n                    (\n                    <jats:italic>Gls<\/jats:italic>\n                    ), that induces gonad morphogenesis. Loss of\n                    <jats:italic>Gls<\/jats:italic>\n                    resulted in animals lacking gonads but having nonproliferative germ cells. We propose that primary germ cells drive gonad development though Gls secretion. The germinal zone in the newly formed gonad provides positive feedback to induce secondary germ cells by activating\n                    <jats:italic>Tfap2<\/jats:italic>\n                    in resident pluripotent stem cells. The contribution of germ cell signaling to the patterning of somatic gonadal tissue may be a general animal feature.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adq8220","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:59:23Z","timestamp":1736344763000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-9676","authenticated-orcid":true,"given":"Camille","family":"Curantz","sequence":"first","affiliation":[{"name":"Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Galway H91 W2TY, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5454-2816","authenticated-orcid":true,"given":"Ciara","family":"Doody","sequence":"additional","affiliation":[{"name":"Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Galway H91 W2TY, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-2990","authenticated-orcid":true,"given":"Helen R.","family":"Horkan","sequence":"additional","affiliation":[{"name":"Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Galway H91 W2TY, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-2208","authenticated-orcid":true,"given":"Gabriel","family":"Krasovec","sequence":"additional","affiliation":[{"name":"Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Galway H91 W2TY, Ireland."},{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris F-75013, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-8832","authenticated-orcid":true,"given":"Paris K.","family":"Weavers","sequence":"additional","affiliation":[{"name":"Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Galway H91 W2TY, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Q.","family":"DuBuc","sequence":"additional","affiliation":[{"name":"Department of Biology, Queens College, The City University of New York, 6530 Kissena Blvd., Flushing, NY 11367, USA."},{"name":"Biology and Biochemistry PhD Programs, CUNY Graduate Center, 365 5th Ave., New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2094-6381","authenticated-orcid":true,"given":"Uri","family":"Frank","sequence":"additional","affiliation":[{"name":"Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Galway H91 W2TY, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00804"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201102"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.03.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20784"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0663"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.061"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00469-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.03.039"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13227-020-00151-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6782"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2016.06.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05506"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78793"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5032-z"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0404-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112687"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-007-0151-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-023-01532-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","unstructured":"D. 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