{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:26:25Z","timestamp":1788312385826,"version":"build-2803163510"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,1,17]]},"abstract":"<jats:p>\n            The rare metal element molybdenum functions as a cofactor in molybdoenzymes that are essential to life in almost all living things. Molybdate can be captured by the periplasmic substrate-binding protein ModA of ModABC transport system in bacteria. We demonstrate that ModA plays crucial roles in growth, multiple metabolic pathways, and ROS tolerance in\n            <jats:italic>Acinetobacter baumannii<\/jats:italic>\n            . Crystal structures of molybdate-coordinated\n            <jats:italic>A. baumannii<\/jats:italic>\n            ModA show a noncanonical disulfide bond with a conformational change between reduced and oxidized states. Disulfide bond formation reduced binding affinity to molybdate by two orders of magnitude and contributes to its substrate preference. ModA-mediated molybdate binding was important for\n            <jats:italic>A. baumannii<\/jats:italic>\n            infection in a murine pneumonia model. Together, our study sheds light on the structural and functional diversity of molybdate uptake and highlights a potential target for antibacterial development.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adq9686","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T19:00:44Z","timestamp":1736967644000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2673-792X","authenticated-orcid":true,"given":"Min","family":"Jiao","sequence":"first","affiliation":[{"name":"Center for Microbiome Research of Med-X Institute, Shaanxi Provincial Key Laboratory of Sepsis in Critical Care Medicine, The First Affiliated Hospital, Xi\u2019an Jiaotong University, Xi\u2019an 710061, 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