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The senolytics,\n                    <jats:italic toggle=\"yes\">o<\/jats:italic>\n                    -vanillin and RG-7112, remove SnCs in human intervertebral discs (IVDs) and reduce SASP release, but it is unknown whether they can treat LBP.\n                    <jats:italic toggle=\"yes\">\n                      sparc\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, with LBP, were treated orally with\n                    <jats:italic toggle=\"yes\">o<\/jats:italic>\n                    -vanillin and RG-7112 as single or combination treatments. Treatment reduced LBP and SASP factor release and removed SnCs from the IVD and spinal cord. Treatment also lowered degeneration scores in the IVDs, improved vertebral bone quality, and reduced the expression of pain markers in the spinal cord. Together, our data suggest RG-7112 and\n                    <jats:italic toggle=\"yes\">o<\/jats:italic>\n                    -vanillin as potential disease-modifying drugs for LBP and other painful disorders linked to cell senescence.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adr1719","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T13:58:26Z","timestamp":1741960706000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":39,"title":["Senolytic treatment for low back pain"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-7396","authenticated-orcid":true,"given":"Matthew","family":"Mannarino","sequence":"first","affiliation":[{"name":"Department of Surgery, Orthopaedic Research Lab, McGill University, Montreal, QC, Canada."},{"name":"ABC-platform (Animal Behavioral Characterization) at the Alan Edwards Centre for Research on Pain, McGill 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