{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:52:22Z","timestamp":1789710742606,"version":"4.0.1"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"48","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,11,29]]},"abstract":"<jats:p>\n            Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%,\n            <jats:italic>P<\/jats:italic>\n            &lt; 1.0 \u00d7 10\n            <jats:sup>\u22127<\/jats:sup>\n            ):\n            <jats:italic>MAP2K2<\/jats:italic>\n            (cg19423175),\n            <jats:italic>LIM2<\/jats:italic>\n            (cg01500140),\n            <jats:italic>CNP<\/jats:italic>\n            (cg13917614),\n            <jats:italic>BLM<\/jats:italic>\n            (cg18247172),\n            <jats:italic>RASA3<\/jats:italic>\n            (cg22348356), and\n            <jats:italic>RUNX3<\/jats:italic>\n            (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery\u2019s molecular influence on offspring health.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adr2084","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T19:01:25Z","timestamp":1732734085000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5605-2016","authenticated-orcid":true,"given":"Siwen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8333-5237","authenticated-orcid":true,"given":"Emma","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sordillo","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-1589","authenticated-orcid":true,"given":"Sof\u00eda","family":"Aguilar-Lacasa\u00f1a","sequence":"additional","affiliation":[{"name":"ISGlobal, Centre for Research in Environmental Epidemiology 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