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Zkscan4 disruption (\n            <jats:italic toggle=\"yes\">\n              Zkscan4\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            ) was sufficient to induce depression-like behaviors following subthreshold social stress. Zkscan4 regulated excitatory synaptic transmission mainly through direct interaction with the\n            <jats:italic toggle=\"yes\">Htr2a<\/jats:italic>\n            promoter and the recruitment of glucocorticoid receptors for the transcriptional repression of 5-hydroxytryptamine receptor 2a (Htr2a). Reduced excitatory synaptic transmission in the hippocampus and stress susceptibility in\n            <jats:italic toggle=\"yes\">\n              Zkscan4\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n            <\/jats:italic>\n            mice were restored by pharmacological inhibition, genetic knockdown of Htr2a, or overexpression of the amino-terminal SCAN domain of Zkscan4 (Zkscan4\n            <jats:sub>1\u2013133<\/jats:sub>\n            ) in cornus ammonis region 3. Our findings demonstrate an essential role of Zkscan4 in promoting stress resilience, suggesting a potential antidepressant effect of Zkscan4\n            <jats:sub>1\u2013133<\/jats:sub>\n            .\n          <\/jats:p>","DOI":"10.1126\/sciadv.adr2291","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:00:21Z","timestamp":1748023221000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Hippocampal Zkscan4 confers resilience to chronic stress\u2013induced depression-like behaviors"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0898-0178","authenticated-orcid":true,"given":"Kai","family":"Gao","sequence":"first","affiliation":[{"name":"Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key laboratory of Mental Health, Chinese Academy of Medical Sciences, Beijing 100191, China."},{"name":"Changping Laboratory, Beijing 102206, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key laboratory of Mental Health, Chinese Academy of Medical Sciences, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-1295","authenticated-orcid":true,"given":"Xiaoxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National 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China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Changping Laboratory, Beijing 102206, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-7401","authenticated-orcid":true,"given":"Dai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key laboratory of Mental Health, Chinese Academy of Medical Sciences, Beijing 100191, China."},{"name":"Changping Laboratory, Beijing 102206, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-8568","authenticated-orcid":true,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Peking 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