{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:53:42Z","timestamp":1782280422178,"version":"3.54.5"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"11","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:p>\n                    Lipid homeostasis is critical to neuronal survival. ATP-binding cassette A (ABCA) proteins are lipid transporters associated with neurodegenerative diseases. How ABCA transporters regulate lipid homeostasis in neurodegeneration is an outstanding question. Here we report that the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    ABCA protein engulfment ABC transporter in the ovary (Eato) regulates phagocytosis-dependent neurodegeneration by playing opposing roles in neurons and phagocytes: In neurons, Eato prevents dendrites and axons from being attacked by neighboring phagocytes; in phagocytes, Eato sensitizes the cell for detecting neurons as engulfment targets. Thus,\n                    <jats:italic>Eato<\/jats:italic>\n                    deficiency in neurons alone causes phagocytosis-dependent neurite degeneration, but additional\n                    <jats:italic>Eato<\/jats:italic>\n                    loss from phagocytes suppresses the neurite degeneration. Mechanistically, Eato functions by removing the eat-me signal phosphatidylserine from the cell surface in both neurons and phagocytes. Multiple human and worm ABCA homologs can rescue\n                    <jats:italic>Eato<\/jats:italic>\n                    loss in phagocytes but not in neurons, suggesting both conserved and cell type\u2013specific activities of ABCA proteins. These results imply possible mechanisms of neuron-phagocyte interactions in neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adr5448","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T13:58:57Z","timestamp":1741787937000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-6502","authenticated-orcid":true,"given":"Xinchen","family":"Chen","sequence":"first","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-3302","authenticated-orcid":true,"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0970-2776","authenticated-orcid":true,"given":"Ankita","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0970-8781","authenticated-orcid":true,"given":"Zixian","family":"Huang","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-5234","authenticated-orcid":true,"given":"Nicolas Vergara","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9824-6816","authenticated-orcid":true,"given":"Ann T.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Chen","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-8095","authenticated-orcid":true,"given":"Chun","family":"Han","sequence":"additional","affiliation":[{"name":"Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24418"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bse0500265"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(99)00170-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0047-8"},{"key":"e_1_3_2_6_2","first-page":"17","article-title":"A-subclass ATP-binding cassette proteins in brain lipid homeostasis and neurodegeneration","volume":"3","author":"Piehler A. 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