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This study designed composite microneedles and ion solutions using calcium silicate bioceramics, which deliver SiO\n            <jats:sub>3<\/jats:sub>\n            <jats:sup>2\u2212<\/jats:sup>\n            directly into myocardial tissue or indirectly via systemic circulation. These interventions modulate the cell microenvironment by regulating CD4\n            <jats:sup>+<\/jats:sup>\n            T\/T helper 17 (T\n            <jats:sub>H<\/jats:sub>\n            17) cells and their interactions with neutrophils and fibroblasts through the forkhead box O (FOXO) signaling pathway. Specifically, SiO\n            <jats:sub>3<\/jats:sub>\n            <jats:sup>2\u2212<\/jats:sup>\n            inhibits the hyperdifferentiation of CD4\n            <jats:sup>+<\/jats:sup>\n            T cells to T\n            <jats:sub>H<\/jats:sub>\n            17 cells by regulating FOXO1 and neutrophils to neutrophil extracellular traps as well as fibroblasts to myofibroblasts by regulating FOXO3, thereby ultimately disrupting the vicious cycle of myocardial inflammation and subsequent fibrotic lesions in iDCM. This discovery indicates that the biomaterial-based strategy may have great potential for the treatment of iDCM.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adr7208","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:58:41Z","timestamp":1744221521000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-9503","authenticated-orcid":true,"given":"Ping","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin 1500086, China."},{"name":"The Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin 150086, 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