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We analyzed each test at weekly intervals from 20 weeks preconception to 80 weeks postpartum, providing detailed temporal profiles. About half of the tests take 3 months to a year to return to baseline postpartum, highlighting the physiological load of childbirth. The precision of the data revealed effects of preconception supplements, overshoots after delivery and intricate temporal responses to changes in blood volume and renal filtration rate. Pregnancy complications\u2014gestational diabetes, preeclampsia, and postpartum hemorrhage\u2014showed distinct dynamical changes. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.<\/jats:p>","DOI":"10.1126\/sciadv.adr7922","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T14:45:32Z","timestamp":1743000332000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":37,"title":["Pregnancy and postpartum dynamics revealed by millions of lab tests"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-876X","authenticated-orcid":true,"given":"Alon","family":"Bar","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3729-8162","authenticated-orcid":true,"given":"Ron","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0512-6847","authenticated-orcid":true,"given":"Netta","family":"Mendelsohn-Cohen","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4361-2805","authenticated-orcid":true,"given":"Yael","family":"Korem Kohanim","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4479-3423","authenticated-orcid":true,"given":"Avi","family":"Mayo","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-8987","authenticated-orcid":true,"given":"Yoel","family":"Toledano","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Helen Schneider Women\u2019s Hospital, Rabin Medical Center, Petah Tikva 4941492, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-5907","authenticated-orcid":true,"given":"Uri","family":"Alon","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.mpaic.2019.05.001","article-title":"Physiology of pregnancy","volume":"20","author":"Mockridge A.","year":"2019","unstructured":"A. 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