{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:43:36Z","timestamp":1791333816810,"version":"4.3.1"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"48","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,11,29]]},"abstract":"<jats:p>\n                    Dengue virus (DENV) is the most widespread mosquito-borne virus worldwide, but no antiviral therapies are available yet. The pan-serotype DENV inhibitor JNJ-A07 has shown potent activity in a mouse model. It remains unknown whether an antiviral drug ingested by mosquitoes could inhibit virus replication and thus reduce transmission to other hosts. Here, we investigated the antiviral activity of JNJ-A07 when administered in the blood meal to\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    mosquitoes. JNJ-A07 blocked DENV-2 transmission by the mosquitoes in both pre-exposure and post-exposure settings. In addition, JNJ-A07 remained in the mosquito bodies for 7 days after blood meal. Reductions of DENV systemic infection in the mosquitoes suggested a potential for decreased proportions of DENV outbreaks in a simulated environment when the mosquitoes ingested JNJ-A07 via the blood meal.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adr8338","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T14:01:25Z","timestamp":1732716085000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["The antiviral JNJ-A07 significantly reduces dengue virus transmission by\n                    <i>Aedes aegypti<\/i>\n                    mosquitoes when delivered via blood-feeding"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-9152","authenticated-orcid":true,"given":"Ana L.","family":"Rosales-Rosas","sequence":"first","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions &amp; Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Goossens","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions &amp; Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-623X","authenticated-orcid":true,"given":"Winston","family":"Chiu","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virology, Antiviral Drug &amp; Vaccine Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-5785","authenticated-orcid":true,"given":"Atreyee","family":"Majumder","sequence":"additional","affiliation":[{"name":"Janssen R&amp;D, Titusville, NJ, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-7424","authenticated-orcid":true,"given":"Alina","family":"Soto","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions &amp; Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4296-1809","authenticated-orcid":true,"given":"Serge","family":"Masyn","sequence":"additional","affiliation":[{"name":"Janssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-2696","authenticated-orcid":true,"given":"Bart","family":"Stoops","sequence":"additional","affiliation":[{"name":"Janssen R&amp;D, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-1443","authenticated-orcid":true,"given":"Lanjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions &amp; Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-0219","authenticated-orcid":true,"given":"Suzanne J. F.","family":"Kaptein","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virology, Antiviral Drug &amp; Vaccine Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-8989","authenticated-orcid":true,"given":"Olivia","family":"Goethals","sequence":"additional","affiliation":[{"name":"Janssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-675X","authenticated-orcid":true,"given":"Leen","family":"Delang","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions &amp; Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(02)00378-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.55"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00026-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0476-8"},{"key":"e_1_3_2_6_2","unstructured":"J.E Cogan Dengue and severe dengue Fact Sheets in World Health Organization (2024); www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue."},{"key":"e_1_3_2_7_2","unstructured":"European Centre for Disease Prevention and Control Local transmission of dengue virus in mainland EU\/EEA 2010-present Dengue: Surveillance and updates (2024); www.ecdc.europa.eu\/en\/all-topics-z\/dengue\/surveillance-and-disease-data\/autochthonous-transmission-dengue-virus-eueea."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001760"},{"key":"e_1_3_2_10_2","unstructured":"Centers for Disease Control and Prevention \u201cSection 5: Travel-Associated Infections & Diseases - Viral\u201d in CDC Yellow Book 2024: Health Information for International Travel L. S\u00e1nchez-Gonz\u00e1lez L. Adams G. Paz-Bailey Eds. (Oxford Univ. Press 2023); www.nc.cdc.gov\/travel\/yellowbook\/2024\/infections-diseases\/dengue."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw649"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2021-0791"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800820"},{"key":"e_1_3_2_14_2","unstructured":"A. Liu UPDATED: Takeda yanks FDA filing for dengue vaccine citing data disagreement with regulator (FiercePharma 2023); www.fiercepharma.com\/pharma\/takeda-yanks-fda-application-dengue-vaccine-citing-data-collection-disagreement."},{"key":"e_1_3_2_15_2","unstructured":"Takeda \u201cTakeda\u2019s QDENGA\u00ae\u25bc (Dengue Tetravalent Vaccine [Live Attenuated]) Approved in Indonesia for Use Regardless of Prior Dengue Exposure\u201d (Takeda 2022); www.takeda.com\/newsroom\/newsreleases\/2022\/takedas-qdenga-dengue-tetravalent-vaccine-live-attenuated-approved-in-indonesia-for-use-regardless-of-prior-dengue-exposure\/."},{"key":"e_1_3_2_16_2","unstructured":"J. D. Rodr\u00edguez Invima aprob\u00f3 vacuna japonesa contra el dengue en pleno incremento de esa enfermedad en el pa\u00eds (Infobae 2023); www.infobae.com\/colombia\/2023\/11\/26\/invima-aprobo-vacuna-japonesa-contra-el-dengue-en-pleno-incremento-de-esa-enfermedad-en-el-pais\/."},{"key":"e_1_3_2_17_2","unstructured":"Vietnam News Agency Ministry licenses vaccines against dengue shingles and pneumococcal 23 [Vietnam+ (VietnamPlus) 2024]; https:\/\/en.vietnamplus.vn\/ministry-licenses-vaccines-against-dengue-shingles-and-pneumococcal-23-post286146.vnp."},{"key":"e_1_3_2_18_2","unstructured":"World Health Organization WHO prequalifies new dengue vaccine (World Health Organization 2024); www.who.int\/news\/item\/15-05-2024-who-prequalifies-new-dengue-vaccine."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903869"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2023.102598"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2020.07.009"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03990-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05790-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad284"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004551"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2008.00740.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007420"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13010108"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-04846-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1923-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105694"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007681"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00867-15"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9050944"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003084"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.292"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.203"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065252"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.67.85"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092971"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004052"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00230-18"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007346"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002311"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.05195-22"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2010.06.001"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773212Y.0000000036"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007187"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adr8338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T14:02:43Z","timestamp":1732716163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adr8338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":47,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2024,11,29]]}},"alternative-id":["10.1126\/sciadv.adr8338"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adr8338","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]},"assertion":[{"value":"2024-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadr8338"}}