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Attempts to replicate the human hand have fallen short of a true biomimetic hybrid robotic hand with tactile sensing. We introduce a natural prosthetic hand composed of soft robotic joints and a rigid endoskeleton with three independent neuromorphic tactile sensing layers inspired by human physiology. Our innovative design capitalizes on the strengths of both soft and rigid robots, enabling the hybrid robotic hand to compliantly grasp numerous everyday objects of varying surface textures, weight, and compliance while differentiating them with 99.69% average classification accuracy. The hybrid robotic hand with multilayered tactile sensing achieved 98.38% average classification accuracy in a texture discrimination task, surpassing soft robotic and rigid prosthetic fingers. Controlled via electromyography, our transformative prosthetic hand allows individuals with upper-limb loss to grasp compliant objects with precise surface texture detection.<\/jats:p>","DOI":"10.1126\/sciadv.adr9300","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T13:58:51Z","timestamp":1741183131000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":111,"title":["A natural biomimetic prosthetic hand with neuromorphic tactile sensing for precise and compliant grasping"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-8494","authenticated-orcid":true,"given":"Sriramana","family":"Sankar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9809-9556","authenticated-orcid":true,"given":"Wen-Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5265-7421","authenticated-orcid":true,"given":"Ariel","family":"Slepyan","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-3943","authenticated-orcid":true,"given":"Mark M.","family":"Iskarous","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-4743","authenticated-orcid":true,"given":"Rebecca J.","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8325-1216","authenticated-orcid":true,"given":"Rene","family":"DeBrabander","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-6085","authenticated-orcid":true,"given":"Junjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4818-2130","authenticated-orcid":true,"given":"Arnav","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-9395","authenticated-orcid":true,"given":"Nitish V.","family":"Thakor","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA."},{"name":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/act9010003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800907"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-3190\/11\/6\/066005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6439\/aaa1d8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0278364915592961"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aai7529"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00170-018-1949-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.robot.2017.11.005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2019.08.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201900317"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"J. 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