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By iron complexation, an asymmetric ALJN is formed on ocular surface via facile sequential instillation. The adhesive polyphenol inner layer binding with ocular surface enables drug loading and sustained release, while the lubricative zwitterionic polymer outer layer prevents eyelid adhesion to ensure comfort. Following instillation, ALJN retains on ocular surface over 24\u00a0hours and reduces blinking frequency to normal level. Moreover, ALJN demonstrates remarkable therapeutic potential in mouse and rabbit models of corneal contusion and alkali burn. This work proposes a comfortable long-lasting topical delivery platform for treating various ocular diseases.<\/jats:p>","DOI":"10.1126\/sciadv.ads0282","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T18:59:41Z","timestamp":1741373981000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["Long-lasting comfort ocular surface drug delivery by in situ formation of an adhesive lubricative Janus nanocoating"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0962-0341","authenticated-orcid":true,"given":"Chuhan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China."},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Center for Basic Medical Research and Innovation in Visual System 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