{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:06:18Z","timestamp":1789157178920,"version":"build-2803163510"},"reference-count":59,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"37","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,9,12]]},"abstract":"<jats:p>\n            Insects, unlike vertebrates, use heteromeric complexes of odorant receptors and co-receptors for olfactory signal transduction. However, the secondary messengers involved in this process are largely unknown. Here, we use the olfactory signal transduction of the aggregation pheromone 4-vinylanisole (4VA) as a model to address this question. When locusts detect 4VA, the pheromone is transported by OBP10 and OBP13 to the OR35\u2013Orco receptor complex, thereby activating downstream pathways in the antenna. A pivotal downstream molecule, the lipid-binding protein Clvs2, facilitates phosphatidylinositol 4,5-bisphosphate transportation across the cytolemma, providing more substrates for inositol trisphosphate (IP\n            <jats:sub>3<\/jats:sub>\n            ) production. PLCe1, a biosynthetic enzyme, boosts IP\n            <jats:sub>3<\/jats:sub>\n            levels in the antennal lobe of the brain. IP\n            <jats:sub>3<\/jats:sub>\n            is responsible for converting chemical signals from the antenna into neural signals, confirming IP\n            <jats:sub>3<\/jats:sub>\n            as a secondary messenger in olfaction perception instead of GPCR in locusts. These findings elucidate the universal function of IP\n            <jats:sub>3<\/jats:sub>\n            in olfactory signal perception, shedding light on the key nodes of insect olfactory signal transduction.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ads1352","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T18:01:02Z","timestamp":1757527262000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Locusts adopt IP\n            <sub>3<\/sub>\n            as a second messenger for olfactory signal transduction"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0157-5971","authenticated-orcid":true,"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China."},{"name":"University of Chinese 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