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In addition, we confirmed improved neuromuscular function from dietary MetR in 5XFAD mice, whose weight was not affected by MetR. We did not observe benefits with TDP inhibition. Single-nucleus RNA and ATAC sequencing of muscle revealed cell type\u2013specific responses to MetR, although MetR did not significantly affect mouse aging epigenetic clock markers. Similarly, an 8-week MetR intervention in a human trial (NCT04701346) showed no significant impact on epigenetic clocks. The observed benefits from late-life MetR provide translational rationale to develop MetR mimetics as an antiaging intervention.<\/jats:p>","DOI":"10.1126\/sciadv.ads1532","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:58:56Z","timestamp":1744811936000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-7172","authenticated-orcid":true,"given":"Ulalume","family":"Hern\u00e1ndez-Arciga","sequence":"first","affiliation":[{"name":"Aging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, 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