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We confirmed these findings in newborn, inflammation-free samples of a CF animal model and further identified ultrastructural alterations in the olfactory epithelium and bulbs of these animals. We established that CFTR, the anion channel whose dysfunction causes CF, is dispensable for odor-evoked signaling in sensory neurons, yet CF animals displayed defective odor-guided behaviors consistent with the morphological and molecular alterations. Our study highlights CF\u2019s major role in modulating epithelial structure and OR expression, shedding light on the mechanisms contributing to olfactory loss in CF.<\/jats:p>","DOI":"10.1126\/sciadv.ads1568","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:58:57Z","timestamp":1740751137000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Cystic fibrosis alters the structure of the olfactory epithelium and the expression of olfactory receptors affecting odor perception"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-4134","authenticated-orcid":true,"given":"Ignacio","family":"Caballero","sequence":"first","affiliation":[{"name":"Infectiologie et Sant\u00e9 Publique, UMR1282, INRAE, University of Tours, 37380 Nouzilly, 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