{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:11:55Z","timestamp":1791324715903,"version":"4.3.1"},"reference-count":66,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"49","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,12,6]]},"abstract":"<jats:p>\n            Computed tomography (CT) scanners are essential for modern imaging but require around 600 projections from various angles. We present x-ray\u2013induced acoustic computed tomography (XACT), a method that uses radiation-induced acoustic waves for three-dimensional (3D) x-ray imaging. These spherical acoustic waves travel through tissue at 1.5 \u00d7 10\n            <jats:sup>3<\/jats:sup>\n            meters per second, much slower than x-rays, allowing ultrasound detectors to capture them and generate 3D images without mechanical scanning. We validate this theory by performing 3D numerical reconstructions of a human breast from a single x-ray projection and experimentally determining 3D structures of objects at different depths. Achieving resolutions of 0.4 millimeters in the\n            <jats:italic>XZ<\/jats:italic>\n            plane and 3.5 millimeters in the\n            <jats:italic>XY<\/jats:italic>\n            plane at a depth of 16 millimeters, XACT demonstrates the ability to produce 3D images from one x-ray projection, reducing radiation exposure and enabling gantry-free imaging. XACT shows great promise for biomedical and nondestructive testing applications, potentially replacing conventional CT.\n          <\/jats:p>","DOI":"10.1126\/sciadv.ads1584","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T18:58:44Z","timestamp":1733511524000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["X-ray\u2013induced acoustic computed tomography: 3D X-ray absorption imaging from a single view"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-2492","authenticated-orcid":true,"given":"Siqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of California, Irvine, Irvine, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-2580","authenticated-orcid":true,"given":"Prabodh Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, University of California, Irvine, Irvine, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-0648","authenticated-orcid":true,"given":"Gerald","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of California, Irvine, Irvine, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4521-7601","authenticated-orcid":true,"given":"Rick J. 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